摘要
用免疫荧光ABC法动态观察了大鼠皮肤创伤愈合过程中转化生长因子β（TGFβ1、β2、β3）·表皮生长因子（EGF）和白介素-6（IL－6）的分布。背部创伤术后1天，创面血痂中五种生长因子免疫染色均呈阳性。术后3天与7天，肉芽组织中密集的成纤维细胞内除TGFβ3、外其余四种生长因子呈阳性，巨噬细胞呈TGFβ1、TGFβ2与IL－6阳性。术后14天与28天，组织内细胞密度降低而其免疫染色性质不变。本文讨论了这些生长因子与创伤愈合的关系。
Immunofluorescent ABC method was employed to trace the distribution of transforming growth factorβ1,β2,β3, (TGFβ1, TGFβ2, TGFβ3) epidermal growth factor (EGF) and interleukin-6 (IL-6) in the wound healing tissue of rat skin. By day l post wounding,' all the five growth factors were positive in scab. By day 3 and 7, in granulation tissue the densely packed fibroblasts were positively stained to the four growth factors except TGFβ3.macrophages were positive to TGFβ1, TGFβ2 and IL-6. By day 14 and 28, the cell density decreased while the staining of the cells to growth factors remained unchanged. The relationship between the growth factors and wound healing is discussed.
出处
《中国组织化学与细胞化学杂志》
CAS
CSCD
1998年第2期203-206,248,共5页
Chinese Journal of Histochemistry and Cytochemistry
关键词
创伤愈合
转化生长因子Β
表皮生长因子
白介素-6
Wound healing
Transforming growth factor β
Epidermal growth factor
Interleukin-6
