摘要
目的 探讨幽门螺杆菌菌株类型与儿童胃、十二指肠疾病类型及胃黏膜炎症程度之间的关系.方法 选择2010年1月至2012年10月江西省儿童医院收治的具有不同程度上消化道症状的112例患儿,其中,幽门螺杆菌(Hp)相关性慢性胃炎(CG) 67例,消化性溃疡(PU) 45例,过免疫印迹法检测患儿血清的CagA及VacA抗体,并观察其胃黏膜的病理变化.结果 112例中,CagA、VacA抗体检出率分别为82.14％和86.61％,两者差异无统计学意义(P＞0.05).CagA、VacA抗体在CG中检出率分别为79.10％和83.58％,在PU中检出率分别为86.67％和91.11％,CagA、VacA抗体在PU、CG中的检出率差异均无统计学意义(均P＞0.05).112例Hp感染患儿中,Ⅰ型菌占80.36％,Ⅱ型菌占11.61％,中间型占8.03％,各型菌株在CG、PU中检出率差异无统计学意义(均P＞0.05).90例Ⅰ型菌株,感染引起胃黏膜中重度炎症占92.22％,轻度炎症占7.78％,而13例Ⅱ型菌株,9例中间型菌株感染引起胃黏膜中重度炎症分别为23.08％及55.56％,差异有统计学意义(P＜0.01).结论 CagA及VacA与CG、PU的发病有关,但不能作为判断CG、PU的依据,当儿童Ⅰ型菌株Hp感染时,对胃黏膜破坏最大,应积极治疗.
Objective To explore the relationship among different types of Helicobacter pylori (HP),the gastroduodenal disease type and the severity of gastric mucosal inflammation in childhood.Methods By western blot method to detect serum antibodies of CagA and VacA obtained from 112 patients infected by HP-related Chronic Gastritis (CG) and Peptic ulcer (PU).and observe the pathologic changes of gastric mucosa.Results In 112 cases,the CagA,VacA antibody detection rate was 82.14％ and 82.14％,no significant difference (P＞0.05).The detection rate of CagA,VacA antibodies in patients with chronic gastritis (CG) was 79.10％ and 83.58％,and in patients with Peptic ulcer (PU) was 86.67％ and 91.11％,The detection rate of CagA,VacA antibody in PU,CG had no obvious difference (P＞0.05).Of 112 cases of children with Hp infection,I type HP accounted for 80.36％,Ⅱ type HP accounted for 11.61％ and intermediate type accounted for 8.03％,No significant differences existed in the detection rate of these three types of HP in CG or PU (P＞0.05); Among the 90 patients with Ⅰ type HP,92.22％ of them caused severe gastric mucosal inflammation,7.78％ of them got mild inflammation.23.08％of 13 patients with Ⅱ type HP and 55.56％ of 9 patients with intermediate type HP got severe gastric mucosal inflammation,which showed that the differences are significant (P＜0.01).Conclusion CagA and VaCA are closely related to the onset of CG and PU,but can not be used as the basis for judging the onset of CG and PU,when children infected with Ⅰ type HP,their gastric mucosa suffers the greatest damage,they should be treated actively.
出处
《中国临床实用医学》
2014年第1期-,共3页
China Clinical Practical Medicine
基金
江西省卫生厅科研课题
