摘要
目的探究红花黄色素注射液对冠心病患者血浆大内皮素(big endothelin,Big ET)与脑钠肽(brain natriuretic peptide,BNP)水平的影响。方法选取唐山市人民医院2012年6月~2014年2月心内科收治的冠心病患者80例,随机分为2组(n=40),予抗血小板聚集、减轻心肌耗氧、缓解疼痛、稳定斑块等常规治疗;实验组在常规治疗的基础上加用红花黄色素注射液100 mg,静脉滴注,1次/d。另选取同期本院门诊体检中心体检志愿者40例为空白组,追踪14 d。对比治疗前后患者Big ET及BNP变化及临床疗效。结果治疗前,常规组、实验组与空白组相比,Big ET、BNP有显著性差异(P<0.05);治疗后,常规组和实验组Big ET、BNP水平均显著下降,与常规组比较,实验组下降更明显,差异具有统计学意义(P<0.05);治疗后实验组临床总有效率高于对照组,差异具有统计学意义(P<0.05)。结论红花黄色素注射液可明显改善冠心病患者Big ET、BNP及临床症状,对临床具有指导意义。
Objective To study the effect of safflower yellow pigment injection on plasma big endothelin(ET) and brain natriuretic peptide(BNP) levels in patients with coronary heart disease. Methods 80 patients with coronary artery disease collected in Tangshan People's Hospital from June 2012 to February 2014 were randomly divided into two groups,40 cases of each group. Both groups were given conventional treatments including antiplatelet,reducing myocardial oxygen consumption,relieving pain,stabilizing plaque and so on; experimental group were given 100 mg safflower yellow pigment injection on the basis of conventional therapy,intravenous infusion,once daily. 40 volunteers for physical examination were selected as blank group,tracked for 14 days. Changes of Big ET and BNP leves and clinical efficacy were compared before and after treatment between two groups.Results Before treatment,compared with blank group,Big ET,BNP levels had significant differences in conventional group and experimental group(P <0.05); after treatment,levels of Big ET,BNP in experimental group and conventional group significantly decreased compared with before treatment,and levels of Big ET,BNP in experimental group significantly decreased compared with conventional group,the differences were statistically significant(P < 0. 05);after treatment,the clinical total effective rate in experimental group was higher than that in control group,the difference was statistically significant(P < 0. 05). Conclusion The safflower yellow injection could significantly improve levels of Big ET,BNP and clinical symptoms in patients with CHD,which has the instructional significance for clinical application.
出处
《中国生化药物杂志》
CAS
北大核心
2014年第5期146-148,共3页
Chinese Journal of Biochemical Pharmaceutics
基金
唐山市科学技术研究与发展计划(12150220B-5)
关键词
红花黄色素
冠心病
血浆大内皮素
脑钠肽
safflower yellow pigment
coronary heart disease
big endothelin
brain natriuretic peptide
