摘要
目的探讨128层螺旋CT灌注成像技术(CTPI)对诊断急性脑梗死及评价患者临床预后的应用价值。方法对67例在甘肃省人民医院住院的发病在24 h内的急性脑梗死患者行CT平扫和CTPI检查,获得了梗死区脑血容量、脑血流量及平均通过时间等参数。在患者入院7天内病情稳定后对患者进行临床神经功能缺损程度评分。对各数据之间的相关性进行统计学分析。结果 CT平扫有38例显示早期脑梗死征象,诊断敏感性为56.72%;CTPI有56例发现脑内灌注异常区,诊断敏感性为83.58%。CTPI示梗死区脑血流量值较健侧脑实质明显下降(P=0.000),梗死区平均通过时间值较健侧脑实质明显延迟(P=0.038)。相关分析显示,脑血容量、脑血流量与临床神经功能缺损程度评分呈负相关(P<0.05),平均通过时间与临床神经功能缺损程度评分呈正相关(P<0.05)。结论 CT灌注成像技术有助于早期诊断急性脑梗死,并可评价患者的临床预后。
Aim To investigate the application value of 128-slice spiral CT perfusion imaging( CTPI) in the diagnosis of acute cerebral infarction and the evaluation of patients prognosis. Methods Nonenhancement CT and CTPI were performed on 67 patients with acute cerebral infarction within 24 hours who were hospitalized in the People's Hospital of Gansu Province. Cerebral blood volume( CBV),cerebral blood flow( CBF) and mean transit time( MTT) of infarction area were obtained. American National Institute of Health stroke scale( NIHSS) scores from each patient were obtained when their conditions became stable in 7 days. Then statistical analysis was made for the correlation between these data. Results 38 cases had been found showing early signs of cerebral infarction by CT scan,and the sensitivity was56. 72%. 56 cases had been found appearing brain perfusion abnormality area by CTPI,and the sensitivity was 83. 58%.The CTPI results showed that CBF value of infarction area was significantly decreased than that of contralateral normal brain parenchyma( P = 0. 000); The MTT value of infarction area was significantly delayed than that of contralateral normal brain parenchyma( P = 0. 038). The correlation analysis showed that CBV and CBF were negatively related with NIHSS score( P < 0. 05),and MTT was positively related with NIHSS score( P < 0. 05). Conclusion CT perfusion imaging is helpful to diagnose the acute cerebral infarction early and to evaluate the clinical prognosis of patients.
出处
《中国动脉硬化杂志》
CAS
北大核心
2015年第6期603-606,共4页
Chinese Journal of Arteriosclerosis
基金
兰州市科技局立项科研课题(2012-1-33)
