摘要
吲哚-3-甲酸是一种重要的有机中间体,被广泛应用于医药与农药的合成。以取代邻硝基甲苯为原料,与N,N-二甲基甲酰胺二甲基缩醛(DMFDMA)反应制得取代2-硝基-β-二甲氨基苯乙烯,再经铁粉和冰乙酸还原环合生成取代吲哚,取代吲哚与三氟乙酸酐经酰化、碱性条件下水解制得5种取代吲哚-3-甲酸类化合物,该合成方法操作简单,条件温和,收率较高。
Indole-3-carboxylic acid is a kind of important organic intermediate,which can be widely used in the synthesis of medicine and pesticide. Substituted 2-nitro-β-dimethylamino styrene was obtained from the reaction of substituted 2-nitrotoluene and N,N-dimethylformamide dimethyl acetal in N,N-dimethylformamide,which was further reacted with iron and acetic acid to give substituted indoles. Five substituted indole-3-carboxylic acids were synthesized from substituted indoles and trifluoroacetic anhydride. The reported synthesis had the advantages of simple post treatment,mild conditions and higher yields.
出处
《化学通报》
CAS
CSCD
北大核心
2015年第4期378-380,共3页
Chemistry
基金
国家自然科学基金项目(21072111
21272131)资助
关键词
取代邻硝基甲苯
取代吲哚-3-甲酸
三氟乙酸酐
Substituted 2-nitrotoluene
Substituted indole-3-carboxylic acid
Trifluoroacetic anhydride
