摘要
目的 :开发降香挥发油的新型给药系统 ,提高药物利用率。方法 :用熔融 超声法制备了降香挥发油固体脂质纳米粒混悬液 ;用HPLC法测定了纳米混悬液的含药量和包封率。结果 :降香挥发油固体脂质纳米粒为类球形实体粒子 ,体积平均粒径为 4 0 .0nm ,含药量为 72 .11% ,包封率为 91.2 7%。结论 :固体脂质纳米粒作为降香挥发油的新型给药系统具有广阔的发展前景。
AIM: To delevop new drug delivery system for volatile oil of lignum dalbergia odoriferae and to improve its effect. METHODS: Solid-lipid-nanopaticals were prepared by hot-dispersiom technique and treated further by sonication; the contents of dispersion and entrapment efficiency of nanoparticles were determined by HPLC. RESULTS: Solid lipid nanoparticles containing volatile oil of lignum dalbergia odoriferae was spherelike; The partical size was 40.0nm; the content of dispersion was 72.1%; entrapment efficiency of nanoparticles was 91.27%. CONCLUSION: Solid-lipid-nanopatical may be a suitable drug delivery system for volatile oil of lignum dalbergia odoriferae.
出处
《中成药》
CAS
CSCD
北大核心
2004年第6期434-437,共4页
Chinese Traditional Patent Medicine
关键词
降香挥发油
固体脂质纳米粒
熔融-超声法
包封率
volatile oil of lignum dalbergia odoriferae
solid lipid nanoparticle
sonication
entrapment efficiency
