摘要
应用光镜、电镜、细胞核DNA含量测定和形态定量分析方法对347例大肠息肉及其癌变的病理变化进行了研究。显示大肠息肉癌变与其组织学类型、体积大小和不典型增生程度三个因素有关。并随腺瘤不典型增生Ⅰ、Ⅱ、Ⅲ级至癌变,细胞核DNA含量和形态测定ING、ISA均值逐渐递增,同时Ⅱ、Ⅲ级不典型增生与腺瘤癌变有相似的超微结构变化。证实大肠腺瘤是大肠癌主要的癌前病变,不典型增生系腺瘤癌变的危险因素。
The pathological changes of 347 cases of colorectal polyps and their malignant degeneration were observed with optical microscopy,electron microscopy,microspec-trophotometry and morphometry.It was found that the malignant degeneration of colorectal polyps was dependent on 3 factors,that is,the histologic type,the size and the grading of dys-plasia.The DNA content and the morphometric ING and ISA increased gradually in grade Ⅰ,Ⅱ and Ⅲ dysplasia and malignant tissue.The ultrastructural changes of grade Ⅱ and Ⅲ dys-plasia were similar to those of adenomas with malignant changes.These findings suggest that colorectal adenoma is a precancerous lesion and dysplasia is a dangerous sign of malignant degeneration of an adenoma.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1993年第4期329-334,共6页
Journal of Third Military Medical University
关键词
肠肿瘤
超微结构
定量分析
DNA
intestinal neoplasms/UL
DNA
neoplasm
morphometry
