摘要
目的 评价1 31 I联合雷公藤多甙治疗Graves眼病 (GO)的价值。方法 将 4 8例Graves病 (GD)合并活动性GO患者随机分为泼尼松组与雷公藤多甙组。泼尼松组用1 31 I加泼尼松治疗 ,雷公藤多甙组用1 31 I加雷公藤多甙治疗 ,治疗 4个月后进行评分判断疗效。对 1年后GO复发率进行比较。结果雷公藤多甙组 (75 0 % )与泼尼松组 (5 8 3% )的GO治疗总有效率差异无显著性 (χ2 =1 5 ,P >0 0 5 ) ,前者 (75 0 % )对软组织炎症的治疗效果明显好于后者 (5 0 0 % ,χ2 =4 9,P <0 0 5 ) ,1年后雷公藤多甙组GO复发率 (33 3% )明显低于泼尼松组 (71 4 % ,χ2 =4 5 7,P <0 0 5 )。结论 雷公藤多甙治疗GO副作用少 ,复发率低 ,优于泼尼松。
Objective To evaluate the therapeutic effectiveness of 131 I and glucoside tripterygium total tablets (GTTT) on Graves' ophthalmopathy (GO). MethodsForty-eight Graves' disease (GD) patients with active GO were randomly assigned either for GTTT therapy or for prednisone therapy group. The group of prednisone used 131 I and prednisone, the group of GTTT used GTTT and 131 I. After four months, the responses to the treatment were evaluated by the standard of Mourits' commending, and the rates of recurrence of GO were compared. Data analysis was performed with χ 2 test. Results There were no significant differences in total effectiveness between the group of GTTT (75.0%) and the group of prednisone (58.3%). The effect of GTTT therapy (75.0%) on inflammation of parenchyma was obviously better than the effect of prednisone (50.0%). The rate of recurrence was markedly less in the group of GTTT (33.3%) than in the group of prednisone (71.4%). Conclusion Side-effect of GTTT on GO is seldom seen, the rate of recurrence is low, and the effectiveness is better compared with that of prednisone.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2004年第3期166-167,共2页
Chinese Journal of Nuclear Medicine
关键词
^131I
雷公藤多甙
治疗
GRAVES眼病
Graves' disease
Radiotherapy
Drug therapy
Immunosuppressive agents
Iodine radioisotopes
