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间质干细胞来源、鉴定、可塑性和应用前景(综述) 被引量:4

The origin, identify, plasticity and prospect of mesenchymal stem cells (A review)
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摘要 间质干细胞 (MSCs)存在于骨髓、肌肉、骨、软骨等部位 ,可分化为中胚层的细胞 ,如成骨细胞、成软骨细胞、成脂肪细胞等 ,亦可分化为内胚层、外胚层的细胞 ,如神经细胞、肝脏细胞、肾脏细胞等 ,同时由于来源广、易于分离扩增和基因转染 ,在临床、科研上有很大的潜在应用价值。 The mesenchymal stem cells are in the places such as bone marrow? muscle? bone and cartilage. They can not only be differentiated into mesodermal cells but also ectodermal and endodermal cells. Meanwhile for the mesenchymal stem cell are easy to gain ?separate ?expand and gene-transfer, there will be extensive and potential applications in clinic and scientific researches.
作者 姜铧 张洹
出处 《暨南大学学报(自然科学与医学版)》 CAS CSCD 2004年第4期468-473,共6页 Journal of Jinan University(Natural Science & Medicine Edition)
基金 广东省自然科学重点基金资助项目 (0 2 1195 )
关键词 间质干细胞 细胞分化 细胞可塑性 mesenchymal stem cell cell differentiate cell plasticity
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参考文献31

  • 1CONGET P A, MINGUELL J J. Phenotypical and functional properties of human bone marrow mesenchymal progenitor[J]. J Cell Physiol, 1999,181(1): 67-73.
  • 2PITTINGER M F, MACKAY A M, BECK S C, et al. Multilineage potential of adult human mesenchymal stem cells [J]. Science, 1999, 284(5411): 143-147.
  • 3WILLIAMS J T, SOUTHERLAND S S, SOUZA J, et al. Cells isolated from adult human skeletal muscle capable of differentiating into multiple mesodermal phenotypes[J]. Am Surg, 1999, 65(1): 22-26.
  • 4BEAUCHAMP J R, MORGAN J E, PAGEL C N, et al. Dynamics of myoblast transplantation reveal a discrete minority of precursors with stem cell-like properties as the myogenic source [J]. J Cell Biol, 1999, 144(6): 1113-1122.
  • 5WAREJCKA D J, HARVEY R, TAYLOR B J, et al. A population of cells isolated from rat heart capable of differentiating into several mesodermal phenotypes[J]. J Surg Res, 1996, 62(2): 233-242.
  • 6FERRARI G, CUSELLA-DE ANGELIS G, COLETTA M, et al. Muscle regeneration by bone marrow-derived myogenic progenitors[J]. Science, 1998, 279(5356): 1528-1530.
  • 7GRONTHTHOS S, ZANNETTINO A C, GRAVES S E, et al. Differential cell surface expression of the STRO-1and alkaline phosphatase antigens on discrete developmental stages in primary cultures of human bone cells [J]. J Bone Miner Res, 1999, 14(1): 47-56.
  • 8CAPLAN A I, ELYADERANI M, MOCHIZUKIO Y, et al. Principles of cartilage repair and regeneration [J]. Clin Orthop, 1997, 342(2): 254-269.
  • 9TOMA C D, SCHAFFER J L, MEAZZINI M C, et al. Developmental restriction of embryonic calvarial cell populations as characterized by their in vitro potential for chondrogenic differentiation[J]. J Bone Miner Res, 1997, 12(12): 2024-2039.
  • 10RAJKUMAR K, MODRIC T, MURPHY L J. Impaired adipogenesis in insulin-like growth factor binding protein-1 transgenic mice[J]. J Endocrinol, 1999, 162(3): 457-465.

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