摘要
A series of modified poly(methyl methacrylate) adsorbents were prepared and their adsorption abilities to endotoxin,which is a component of the outer membrance of Gram-negative bacteria,were compared. The results showed that the adsorbent modified by dimethylamine ligand with a long spacer had the best capacity for adsorbing endotoxin. The adsorbent P-N4,having a hydroxyl group at β -site of the ligand,could form the hydrogen bond with phosphate group. The electrostatic interaction,hydrogen bond and cooperative effect of octatomic ring worked simultaneously. All these factors are responsible for the strong interactions between endotoxin molecule and the adsorbent.
A series of modified poly(methyl methacrylate) adsorbents were prepared and their adsorption abilities to endotoxin,which is a component of the outer membrance of Gram-negative bacteria,were compared. The results showed that the adsorbent modified by dimethylamine ligand with a long spacer had the best capacity for adsorbing endotoxin. The adsorbent P-N4,having a hydroxyl group at β -site of the ligand,could form the hydrogen bond with phosphate group. The electrostatic interaction,hydrogen bond and cooperative effect of octatomic ring worked simultaneously. All these factors are responsible for the strong interactions between endotoxin molecule and the adsorbent.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2004年第8期1465-1467,M010,共4页
Chemical Journal of Chinese Universities
基金
国家"九七三"计划(批准号 :G19990 64 70 7)
国家自然科学基金(批准号:5 0 3 73 0 2 1)
教育部博士学科点基金 (批准号 :2 0 0 3 0 0 5 5 0 3 8)
南开大学科技创新基金资助
关键词
内毒素
吸附
血液灌流
Endotoxin
Adsorption
Hemoperfusion.
