摘要
[目的]探讨血管内皮生长因子(VEGF)、CD44v6在甲状腺癌中的表达以及与淋巴结转移和预后的关系。[方法]应用免疫组织化学SP法检测82例甲状腺癌、12例甲状腺良性病变中VEGF、CD44v6的表达。[结果]甲状腺癌组织中VEGF、CD44v6的表达明显高于良性病变(P<0.01),VEGF和CD44v6的表达与甲状腺癌淋巴结转移关系密切(P<0.01),与组织学类型无关(P>0.05)。[结论]VEGF、CD44v6表达增高对甲状腺癌淋巴结转移有促进作用,可作为监测肿瘤发生、复发及判断预后的指标。
To investigate the expression of vascular endothelial growth factor(VEGF)and its relation-ship with CD44v6,lymph node metastasis and prognosis in thyroid carcinoma(TC).VEGF,CD44v6protein expression in82cases of TC and12cases with benign thyroid lesions were studied by streptavidin/perox-idase(SP)immunohistochemistry technique.The expression of VEGF and CD44v6was significantly dif-ferent between malignant thyroid tumors and benign lesions(P<0.01).In addition,VEGF and CD44v6protein ex-pression correlated significantly with lymph node metastasis(P<0.01)and had no difference in three histological types(P>0.05).[Conclusion]The increase of VEGF and CD44v6may promote lymph node metastasis and they can be regarded as valuable molecular markers for the tumor progression,recurrence and prognosis.
出处
《肿瘤学杂志》
CAS
2004年第4期223-225,共3页
Journal of Chinese Oncology
