摘要
目的 探讨参附注射液在体外循环 (CPB)心内直视手术中的心肌保护作用。方法 6 0例接受心内直视手术患者随机分为对照组和观察组。对照组在全麻低温体外循环下行心内直视手术 ,围术期对症支持处理 ;观察组在对照组方法的基础上加用参附注射液 ,方法为术前 5d静滴参附注射液 2ml/ (kg·d) ,术中建立CPB后滴入 2ml/kg ,并予维持至升主动脉开放后 10min。于升主动脉阻断前 ,开放后 5 ,10min从冠状静脉窦取血 2ml,测定超氧化物歧化酶 (SOD)、丙二醛 (MDA)含量 ;升主动脉阻断前 ,停CPB后 4 ,2 4 ,4 8h从中心静脉取血 2ml测定肌酸激酶同工酶 (CK-MB)及心肌肌钙蛋白I(cTn -I)水平。结果 观察组SOD含量高于对照组 ,而MDA、CK -MB、cTnI均低于对照组 (P <0 .0 5或P <0 .0 1)。结论 围术期参附注射液在心内直视手术中可减轻心肌缺血再灌注损伤 。
Objective To investigate the myocardium protection of Shenfu injection(SFI) during open heart surgery with cardiopulmonary bypass(CPB). Methods 60 cases scheduled for cardiac surgury were randomly divided into two groups: control group(n=30) and test group(n=30).In the control group the treatment was common,and in the test group Shenfu injection was injected by intravenous drip for 2ml/(kg·d).Blood samples were withdrawn from coronary venous sinus before cross-clamping and 5 minutes、10 minutes after aorta declamping,to measure the levels of superoxide dismutase(SOD) and the content of malondialdehyde(MDA).Blood samples were withdrawn from central vein before ross-clamping and 4 hours,24 hours,48 hours after CPB, to test the serum cardial troponin I(cTnI),creatine phosphokinase isoenzyme(CK-MB). Results 5 minutes,10 minutes after aorta declamping,SOD levels of plasma were higher in the test group vs the contol group while MDA levels were lower.4 hours,24 hours,48 hours after CPB,CK-MB and cTnI levels were lower in the test group vs the control group(P<0.05 or P<0.01). Conclusion Shenfu injection may reduces myocardial reperfusion injury and has evident cardiacprotective in open heart operation with cardiopulmonary bypass.
出处
《中国心血管病研究》
CAS
2004年第9期699-701,共3页
Chinese Journal of Cardiovascular Research
关键词
心肺转流术
心肌再灌注损伤
心肌保护
参附注射液
cardiopulmonary bypass
myocardial reperfusion injury
myocardial protection
Shenfu injection
