摘要
目的 :探讨羟甲基戊二酰辅酶A还原酶抑制剂氟伐他汀对SD大鼠心肌梗死后心室重塑的过程及心功能的影响。方法 :SD大鼠冠状动脉前降支结扎形成心肌梗死 ,2 4h后存活的大鼠随机分成心肌梗死 (AMI)对照组和氟伐他汀治疗组 ,治疗组予以氟伐他汀 2 0mg·kg-1·d-1灌胃给药 ,对照组予以蒸馏水灌胃 ;另设假手术组。 8周后进行心脏超声、血液动力学检测判定心脏功能和进行心脏形态学分析 ;同时检测血浆总胆固醇 (Tch)、肌酐 (Cr)、天冬氨酸氨基转移酶 (AST) ,NO2 -/NO3 -、谷胱甘肽过氧化物酶 (glutathioneperioxidase,GSH -PX)以及血浆、心肌脂质过氧化物 (LPO)水平。结果 :氟伐他汀组血浆Tch水平与AMI组比较没有显著性差异 ,平均主动脉压和心率差别无显著性 ,显著降低了左室舒张末压和减少了肺相对重量 (P <0 0 5 ) ;减少了右室相对重量、左室后壁厚度、肺相对重量和心肌纤维化 (P <0 0 5 ,P <0 0 1) ;降低了血浆和心肌的LPO的水平 ,抑制NO2 -/NO3 -的过度表达 ,增加了GSH -PX的表达 (P <0 0 5 ) ;血浆Cr和AST水平无显著差别 (P >0 0 5 )。结论 :氟伐他汀改善大鼠AMI后心室重塑 ,相对延缓心力衰竭的进展 ;
AIM: To clarify the protective effect of long-term administration of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor fluvastatin on ventricular remodeling after myocardial infarction (MI) in rats and its mechanisms. METHODS: Myocardial infarction were established by ligated left coronary anterior artery in SD rats, 24 hours after the operation, the survival rats were treated by gavage fluvastatin (20 mg·kg^(-1)·d^(-1)) or distilled water for 8 weeks. Doppler echocardiography, homodynamic and cardiac histomorphometry were used to assess the ventricular remodeling and cardiac function. The plasma levels of total cholesterol (Tch), creatinine (Cr), glutamic-oxal (o) acetic transaminase (AST), lipid peroxidation (LPO), glutathione perioxidase (GSH-PX), nitrogen monoxide (NO_2^-/NO_3^-) were detected. RESULTS: The Tch, Cr and AST were not significant difference in groups. Left ventricular end-diastole pressure, right relative weight, left ventricular posterior wall thickness, collagen volume fraction and the lung weight were decreased in AMI+fluvastatin group compared to AMI group (P<0.05, P<0.01); The levels of LPO, NO_2^-+NO_3^- in plasma and LPO in myocardium decreased, but plasma GSH-PX level increased in AMI+fluvastatin group (P<0.05). CONCLUSION: Fluvastatin ameliorates the ventricular structural remodeling in a rat model of infarction, and delays the development of heart failure. The anti-oxidation mechanism of fluvastatin may take part in this process.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2004年第8期1444-1448,共5页
Chinese Journal of Pathophysiology
关键词
氟伐他汀
心肌梗死
心室重塑
大鼠
Fluvastatin
Myocardial infarction
Ventricular remodeling
Rats
