摘要
目的 研究重症肌无力 (MG)患者血清可溶性白介素 2受体 (SIL 2R)滴度与肌群受累程度以及SIL 2R与大剂量糖皮质激素冲击治疗过程中病情一过性加重的关系。方法 对 30例MG患者采用改良Osserman法分型 ,将受累骨骼肌群分成 7组 ,肌无力严重程度采用 5等 4分制记分法 ,记录其绝对积分作为肌无力程度的参数 ;用ELISA法测定其血清中SIL 2R滴度。分析肌无力程度与SIL 2R滴度之间的相关性。结果 患者组与对照组SIL 2R及肌无力积分比较差异均有显著性 (均P <0 0 1)。各型MG患者肌无力积分与SIL 2R滴度之间均呈显著正相关 (r=0 78,P <0 0 0 1) ,但在大剂量糖皮质激素冲击治疗过程中病情一过性加重时 ,肌无力积分与SIL 2R无明显相关性 (r=0 4 0 ,P >0 0 5 )。结论 MG患者存在细胞免疫异常 ,SIL
Objective To study the relationship between serum soluble interleukin-2 receptor (SIL-2R) titer and severity of involved muscles and transient aggravation due to large dose corticosteroid therapy in patients with myasthenia gravis.Methods 30 severe patients with MG were classified according to improved Osserman method. The involved voluntary muscles were divided into seven groups. The severity of MG was recorded with five grades and four parts formulation. The absolute integral was taken as the index of MG degree. ELISA was used to measure the titer of serum SIL-2R.Results Remarkable difference was found between patient group and control group both in the SIL-2R titer and the severity of MG(all P<0.01). Significant correlation existed between the severity of MG and SIL-2R titer( r=0.78, P<0.001). No significant correlation existed between the scores in patients with MG and SIL-2R titer( r=0.40, P>0.05) when the cases aggravated transiently during large-dose corticosteroid therapy.Conclusion Cell immunity is abnormal in patients with MG. SIL-2R may reflect the severity of involved muscles.
出处
《临床神经病学杂志》
CAS
2004年第4期253-254,共2页
Journal of Clinical Neurology
