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新型抗血栓药物作用机制研究进展 被引量：6

Research progress in thrombosis and mechanism of new antithrombotic agents
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摘要 根据已有文献报道 ,综述了血栓形成和新型抗血栓药物作用机制的研究进展。血栓形成的病理生理涉及内皮细胞功能异常和细胞黏附功能异常。新型抗血栓药物主要有FⅩa抑制剂、GPⅡb/Ⅲa受体抑制剂、以内皮细胞为靶点的抗血栓药物。 Literatures available was reviewed on the thrombosis and mechanism of new antithrombotic agents.The pathophysiology of the thrombosis involves dysfunction of endothelium and cell adhesion.The new antithrombotic drugs include factor Ⅹa inhibitors, GPⅡb/Ⅲa receptor blocking agents and the drugs modulating the function of endothelium.
作者 陈蓉 谢梅林
机构地区 苏州大学医学院药理学教研室
出处 《中国药理学通报》 CAS CSCD 北大核心 2004年第8期857-860,共4页 Chinese Pharmacological Bulletin
关键词 血栓形成 抗血栓药 作用机制 thrombosis antithrombotic agents mechanism
分类号 R-05 [医药卫生] R364.15 [医药卫生—病理学]
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参考文献18

  • 1陈冬梅,慕邵峰,汪海.激活血管内皮细胞乙酰胆碱作用靶标的抗血栓作用及其分子机制[J].中国药理学通报,2002,18(5):527-531. 被引量：38
  • 2Dadik Varon D, Tamarin I, Zivelin A et al. Homocysteine and oxidized low density lipoprotein enhanced platedlet adhesion to endothelial cells under flow condition:distince mechanisms of thrombogenic modulation[J]. Thromb Haemost, 2000,83(2): 338-44.
  • 3Pearson JD. Endothelial cell function and thrombosis[J]. Baillieres Best Pract Res Clin Haematol, 1999,12(3):329-41.
  • 4Midorikawa S, Sanada H, Hashimoto S et al. Enhancement by homcysteine of plasminogen activaror inhibitor-1 gene expression and secretion from vascular endothelial and smooth muscle cells[J]. Biochem Biophys Res Commun, 2000,272(1):182-5.
  • 5Hasenstab D, Lea H, Clowes AW. Local plasminogen activator inhibitor type 1 overexpression in rat carotid artety enhances thrombosis and endothelial regeneration while inhibiting intimal thickening[J]. Arerioscler Thromb Vasc Biol, 2000,20(3): 853～9.
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二级参考文献8

  • 1Midorikawa S, Sanada H, Hashimoto S,Watanabe T. Enhancement by homcysteine of plasminogen activaror inhibitor-Ⅰ gene expression and secreetion from vascular endothelial and smooth muscle cells, Biochem Biophys Res Commun. 2000, 272 (1): 182 -185.
  • 2Hasenstab D, lea H, Clowes AW. Local plasminogen activator inhibitor type Ⅰ overexpression in rat carotid artery enhances thrombosis and endothelial regeneration while inhibiting intimal thickening. Arerioscler Thromb Vasc Biol. 2000, 20(3): 853 - 226.
  • 3Marsuno H, Kozawa O, Niwa M, Ueshima S,Matsuo O, collen D, Uematsu T. Differential role of components of the fibrnocytic system in the formation and removal of thrombus induced by endothelial injury. Thromb Haemost. 1999, 81 (4): 601 -604.
  • 4Reil TD, Moore WS, Kashyap VS, Neness,Gelabert HA, Quinones Baldrich WJ. The effects of thrombosis, thrombectomy and thrombolysis on endothelial function. Eur J Vasc Endovasc Surg. 2000, 19(2): 162 -168.
  • 5Sagripanti A, Carpi A. Antithrombotic and prothrombotic activities of the vascular endothelium. Biomed Pharmacother. 2000, 54(2): 107- 111.
  • 6Dadik Varon D, Tamarin Ⅰ, Zivelin A,Salomon O4 Shekman B, Savion N. Homocysteine and oxidized low density lipoprotein enhanced platedlet adhesion to endothelial cells under flow conditions: distince mechanisms of thrombogenic modulation. Thromb Haemost. 2000, 83 (2): 338 - 344.
  • 7Pearson JD. Endothelial cell function and thrombosis. Baillieres Best Pract Res Clin Haematol. 1999, 12(3): 329 - 341.
  • 8贾国栋,龙超良,刘国树,汪海.大、小动脉内皮细胞乙酰胆碱作用靶标药理学特性的比较[J].中国应用生理学杂志,2002,18(3):252-256. 被引量：13

共引文献43

同被引文献47

引证文献6

二级引证文献39

中国药理学通报
2004年 第8期

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