摘要
目的 研究制备阿昔洛韦缓释片最佳工艺。方法 以羟丙甲纤维素和卡波普为亲水凝胶型骨架材料 ,聚乙烯吡咯烷酮溶液为黏合剂 ,采用湿法制粒压片 ,制备阿昔洛韦缓释片。进行体外释放度试验 ,并与普通片剂进行比较。结果与结论 研制的缓释片缓释效果良好 ,比普通片有更好的释药性能 。
OBJECTIVE To achieve an optimum manufacturing process for aciclovir sustained-release tablets. METHOD Hydroxypropylmethylcellulose and Carbomer as carriers, and 5% polyvinglpyrrolidone solution as adhesive, acyclovir sustained-release tablets were prepared by wetting granulation method.The release rates of the tablets were determined and compared with common tablets.RESULTS & CONCLUSION The sustained-release tablets had an expected sustained-release quality,and the drug release pattern was in accorded with the Higuich kinetics.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2004年第4期276-278,共3页
Chinese Journal of Modern Applied Pharmacy
关键词
阿昔洛韦
缓释片
羟丙甲纤维素
卡波普
acyclovir
sustained-releasetablets
hydroxypropylmethylcellulose
Carporml
