摘要
目的 :探讨新型可降解材料聚己内酯 (PCL)在生物体内的降解性质。方法:将 PCL 样品植入鼠背部肌肉 ,观察植入 3、6、9、12周时的 PCL重量、分子量、弯曲强度、弯曲模量及扫描电镜下表面形态的变化。结果 :在植入 12周时 ,PCL失重百分比为 7.6 % ,分子量下降约 15 % ,弯曲强度由植入前的 (31.5 2± 2 .94 ) m Pa变化为 (2 9.96± 1.33) m Pa,弯曲模量由植入前的 (2 4 2 .32± 16 .0 6 ) m Pa变化为 (2 31.0 5± 2 3.30 ) m Pa。结论:PCL降解速度慢 ,初始强度高 ,力学强度持续时间长 ,更适于作为填充骨缺损的生物材料。
Objective: To investigate the biodegradation of synthetic polycaprolactone (PCL) in vivo. Methods: Newly synthesized PCL were implanted into muscles of rats. After 3,6,9 and 12 weeks,weight lose, molecular weights,thermodynamic,mechanical changes and SEM were measured to observe the biodegradation of PCL. Results: The weight lose of PCL was 7.6%,12 weeks after operation,molecular weights were decreased by less than 15%,bending strength decreased from (31.52±2.94) mPa to (29.96± 1.33) mPa,bending model decreased from (242.32±16.06) mPa to (231.05±23.30) mPa. Ultramicromorphologic and thermodynamic changes of PCL were slight. Conclusions: Biodegradation of PCL was slower than other synthetic materials such as PLA and PGA. PCL had a higher initial mechanics and was maintained longer. PCL might be applied as a kind of material more suitable to internal fixation.
出处
《新疆医科大学学报》
CAS
2004年第4期323-325,共3页
Journal of Xinjiang Medical University
基金
新疆医科大学博士后基金资助项目 ( 2 0 0 2 -博士后 -0 4)
关键词
聚己内酯
生物降解性
力学
超微形态
polycaprolactone
biodegradation
mechanics
ultramicromorphologic
