摘要
目的探讨发生狼疮性癫痫的相关因素并与其他重症神经精神性狼疮(NPLE)相比较。方法1990～2002年我院住院的重症NPLE患者108例,其中癫痫患者44例,占40.7%,对其各项临床指征进行回顾性分析。结果单因素分析显示癫痫组患者皮肤黏膜病变发生率显著低于其他脑病患者(P<0.01);血肌酐、三酰甘油、感染发生率、脑电异常显著高于其他脑病患者(P<0.05);是否应用大剂量静脉滴注免疫球蛋白(IVIg)联合治疗亦与癫痫发生相关(P<0.05)。多因素回归分析示,血三酰甘油、脑电异常进入多元回归方程。结论上述临床指征与狼疮性癫痫发生相关,其中血三酰甘油、脑电异常是重要的临床相关因素。
Objective To investigate the risk factors of epilepsy in the patients with neuropsychiatric lupus(NPLE). Methods A retrospective cohort study was employed. One hundrand and seven NPLE patients in our hospital from 1990 to 2002 were included in the study. Among those patients, there were 44 cases of epilepsy, accounting for 40.7%.Results Compared with that in the control group , the dermatosis incidence was obviously lower in the patients with epilepsy (P<0.01). Single factor correlation analysis showed that the serum creatinine, the serum triglyceride, the infection rates, the EEG findings and intravenous immunoglobulin therapy were related to the onset of epilepsy (P<0.05). Multi-factor regression analysis showed that only the serum triglyceride and the EEG findings entered the multi-factor logistic equation. Conclusions The above mentioned factors are related to the onset of epilepsy under NPLE. The serum triglyceride and the EEG findings are the most important risk factors.
出处
《诊断学理论与实践》
2004年第4期249-250,256,共3页
Journal of Diagnostics Concepts & Practice
