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新型非甾体抗炎药darbufelone mesilate的合成工艺研究 被引量：3

Studies on the synthetic process of darbufe lone mesilate,a new nonsteroidal anti-inflammatory drug
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摘要 目的合成新型非甾体抗炎药环氧化酶 2和 5 脂氧合酶双重抑制剂darbufelonemesilate。方法以 2 ,6 二叔丁基 4 甲基苯酚为起始原料 ,经 3步反应制得目标化合物 ,其结构经1H NMR谱和MS谱确证。结果对各步反应条件进行了优化 ,总收率达到 5 2 6 % ,较文献收率提高 2 0 %。结论合成路线简便可行 。 Aim To synthesize darbufelone mesilate ,a new nonster oidal anti-inflammatory drug.Method The target compound was prepare d through a three-step reaction from 2,6-di-tert-butyl-4-methyl phenol .Its structure was con firmed by 1H-NMR and MS.Result The reaction method was imp roved and the total yield was 58.1%,which was 20% higher than that reported in the literature. Conclusion The synthetic route is convenient for the darbufelone mesilate synthesis and the process may be used in industry.
作者 曲虹琴 赵冬梅 程卯生
机构地区 哈药集团生物工程有限公司 沈阳药科大学制药工程学院
出处 《中国药物化学杂志》 CAS CSCD 2004年第5期298-300,M005,共4页 Chinese Journal of Medicinal Chemistry
关键词 药物化学 工艺改进 化学合成 darbufelone mesilate 非甾体抗炎药 medicinal chemistry process improvement chemical sy nthesis darbufelone mesilate NSAIDs
分类号 TQ464 [化学工程—制药化工]
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参考文献11

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同被引文献38

  • 1张志德,袁西福,陈玉琴,孟德素,王勇.对羟基苯甲腈合成方法的改进[J].化学试剂,2005,27(3):181-182. 被引量：7
  • 2闵真立,姜凤超,张奇.3-取代吲哚酮类化合物的合成及抗肿瘤活性[J].中国药物化学杂志,2005,15(3):129-132. 被引量：10
  • 3冯润良,宋智梅,郑赓修.非甾体抗炎药达布飞龙的合成[J].齐鲁药事,2007,26(1):41-43. 被引量：1
  • 4袁淑军,方海林,邱玉珠.苯甲腈系列化合物的合成及其缓蚀性能的研究[J].精细石油化工,1997,14(2):31-34. 被引量：5
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中国药物化学杂志
2004年 第5期

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