摘要
目的 :为了探讨磷烧伤过程中形成的磷酸的毒性作用。方法 :通过于健康Wistar大鼠背部注射磷酸溶液的方法 ,确定 5 0 %与 10 0 %致死量 (D5 0与D10 0 )。参考标准 2 0mg/cm2 磷烧伤动物模型创面的残留磷含量 ,选取 4 5 %磷酸溶液制作磷酸烫伤模型 ,比较磷酸烫伤组 (Ⅰ )、磷烧伤组 (Ⅱ )、汽油烧伤组 (Ⅲ )和热水烫伤组 (Ⅳ )伤后的大鼠死亡率。结果 :大鼠D5 0与D10 0分别为 110mg与 15 0mg磷酸 ;Ⅰ、Ⅱ组动物死亡率相似 (6 0 %以上 ) ,显著高于Ⅲ、Ⅳ组的 30 %。结论 :磷烧伤在磷烧伤过程中形成的大量磷酸 ,是磷烧伤中毒的主要原因。
Objective:In order to evaluate the toxicity of phosphate produced as phosphorus burns occurred. Methods:The dosage of phosphate caused 50% and 100% death (D50 and D100) were determined by subcutaneous injection of phosphate at different concentrations. According to the level of residual phosphorus within wounds following standard phosphor burns, rat models of phosphate burn were made by contacting with 45% phosphate solution for 30 sec. The mortalities of rats in phosphate burn group(Ⅰ) were compared with other groups including phosphor burn(Ⅱ), gasoline burn(Ⅲ) and hot water burn(Ⅳ). Results:The D50 and D100 of phosphate in rats were 110 and 150mg respectively.The mortalities of rats in Ⅰ?Ⅱgroups were similar (about 60%), but significantly higher than Ⅲ?Ⅳ groups. Conclusion:While burning phosphor causes thermal injur to skin, there produces quite amounts of phosphate,which likely leads to phosphate intoxication.
出处
《军医进修学院学报》
CAS
2004年第4期286-287,共2页
Academic Journal of Pla Postgraduate Medical School
关键词
磷烧伤
实验
汽油烧伤
磷酸烫伤
死亡率
rats
burns,chemical
phosphoric acids
poisoning
mortality
