摘要
目的 探讨透明细胞肉瘤的临床病理特点及诊断与鉴别诊断要点。方法 对 4例透明细胞肉瘤进行眼观、HE染色和免疫组化检测。结果 发病部位 3例在下肢 ,1例在上肢。肿块均无明显包膜。镜检 :肿瘤细胞呈结节状分布 ,周围纤维组织分隔。瘤细胞呈相对一致的圆形或梭形 ,胞质丰富透亮 ,有明显的核仁 ,核分裂象少见。免疫组化标记肿瘤细胞显示S 10 0蛋白 ,HMB4 5及vimentin阳性 ,CK及CD34均呈阴性。结论 透明细胞肉瘤的诊断应结合临床与病理形态学特征 ,免疫组化检查具有鉴别诊断价值。
Objective To investigate the clinicopathological characteristics and key points of diagnosis. Methods Four cases of clear cell sarcoma were studied by HE and immunohistochemical method. Results All primary tumors were located in the deep soft tissues of the lower (3 cases) or upper (1 case) limbs. Histologically, the architecture was fascicular with lobular arrangement of cells delimited by delicate fibrous septa intimately bound to tendons or aponeuroses. Tumoral cells were round or fusiform with abundant clear cytoplasm sometimes epithelioid with round nuclei and prominent nucleoli. All cases were found showed positive immunostaining for HMB45, S-100 protein and Vimentin, and negative for CK and CD34. Conclusion The diagnosis of clear cell sarcoma depends on the clinicopathological characteristics. Immunohistochemistry analysis plays an important role in the differential diagnosis.
出处
《安徽医科大学学报》
CAS
2004年第5期394-396,共3页
Acta Universitatis Medicinalis Anhui
