摘要
目的 :通过高分辨率CT了解严重烫伤早期血 脑屏障的开放情况。 方法 :建立烫伤 30 %和 5 0 %的兔实验模型各 15只 ,在烫伤前、烫伤后 1、2、3、4、5h和 6h分别对兔脑进行CT平扫及增强扫描 ,观察其变化。 结果 :烫伤后 6h ,烫伤面积为 30 %的兔有 4只在增强后有改变 ,烫伤面积为 5 0 %的 15只兔在增强后均有改变。 结论 :烫伤面积越大 ,血 脑屏障损伤、破坏越明显 ,血 脑屏障开放的时间就越早 。
Objective:The purpose of our experiment was to use CT to observe the opening of BBB at the early stage of severely scalded rabbits. Methods:Healthy male New Zealand white rabbits were used to establish 30% and 50% TBSA Ⅲ°scalded model. Using high resolution spiral CT (SCT), the brain parenchyma were observed when plain CT scan and contrast-enhanced CT were performed. Results:CT image changes were found in 4 cases at 6 hour after scald of 30% TBSA Ⅲ°scalded rabbits, while CT image changes were found in all cases at 6 hour after scald of 50% TBSA Ⅲ°scalded rabbits. Conclusion:The larger TBSA is Ⅲ°scalded, the earlier BBB is opening . BBB of 50% TBSA Ⅲ°scalded rabbits are wider than that of 30% TBSA Ⅲ°scalded rabbits
出处
《医学研究生学报》
CAS
2004年第10期874-876,共3页
Journal of Medical Postgraduates
基金
全军"九五"重点课题基金资助项目 (批准号 :96L0 43 )
关键词
烫伤
血脑屏障
高分辨率CT
增强
Severe scald
Blood-brain barrier
Computed tomography
Contrast-enhancement
