摘要
目的 探讨糖皮质激素在严重急性呼吸综合征 (SARS)治疗中的作用。方法 对 2 0 0 3年 1月～ 5月在本院收治的 99例SARS患者的临床治疗进行回顾性分析。结果 糖皮质激素多采用早期、小剂量、短疗程方案。激素组 4 6例 ,非激素组 5 3例。激素组与非激素组年龄与性别构成比差异均无统计学意义(P >0 0 5 ) ;退热时间和肺部炎症吸收时间 ,激素组分别为 6 3±3 5天和 1 8 2± 7 8天 ,非激素组分别为 8 1± 3 2天和 2 1 7±8 9天 ,两组比较差异有统计学意义 (P <0 0 5 )。结论 早期、小剂量、短疗程使用糖皮质激素能明显缩短SARS的病程 。
Objective To explore the effect of glucocorticoid on severe acute respiratory syndrome (SARS). Methods The clinical histories of 99 SARS patients admitted to our hospital from January to May 2003 were reviewed. Results Glucocorticoid was used mostly in early phase, with small dosage and short period of treatment. There were 46 cases in glucocorticoid group and 53 cases in non glucocorticoid group. The mean ages and gender ratios in glucocorticoid and non glucocorticoid group were comparable (both P >0 05). The mean period of fever (6 3±3 5d) and the mean period of complete resolution of the inflammation in lung (18 2±7 8d) were both significantly shorter in glucocorticoid group compared with non glucocorticoid group (8 1±3 2d,21 7±8 9d, respectively) (both P >0 05). Conclusions The administration of glucocorticoid in early phase of SARS in small dosage and short term regimen could shorten the course of the disease and accelerate resolution of inflammation in the lung
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2004年第9期752-753,共2页
Medical Journal of Chinese People's Liberation Army
基金
SARS军队指令性课题 (编号 0 3F0 0 5)
