摘要
目的 探讨胆汁反流在大鼠急性颅脑损伤后应激性溃疡中的作用。方法 采用改良的Allen法建立大鼠颅脑损伤模型 ,检测应激后 1、3、6、2 4h胃液、血胆汁酸含量 ,胃液pH值与溃疡指数 ,并与假手术组对照比较。结果 应激组与假手术组相应时段比较 ,胃液胆汁酸含量明显增高 (P <0 .0 5～0 .0 1 ) ,随着应激时间的延长 ,胃内胆汁酸的含量逐渐增加 (P <0 .0 5 ) ,胃黏膜的损伤亦逐渐加重 (P <0 .0 5 ) ,其 6、2 4h组与假手术组相应时段比较差异有统计学意义 (P <0 .0 1 ) ,且胃胆汁酸含量与溃疡指数呈正相关 (r =0 .5 5 ,P <0 .0 1 ) ,而应激组与假手术组血中胆汁酸含量及胃内pH值的变化则不大 (P >0 .0 5 ) ,它们与溃疡指数之间亦无相关性 (P >0 .0 5 )。结论 胆汁反流参与颅脑损伤应激性溃疡的发病 ;
Objective To study the role of bile reflux in the pathogenesis of stress ulcer after acute brain trauma in rat. Methods The animal model was reproduced by Allen's method with modification. The bile acid concentration in the stomach and blood, the pH value of the gastsic content, and ulcer index (UI) were assayed 1, 3, 6, 24 hour after the stress, and they were compared with that of sham injury group. Results In stress group, compared with sham injury group, the amount of bile acid in the stomach was notably increased( P <0.05, P <0.01). With the prolongation of stress time, the amount of bile acid in the stomach showed a tendency of gradual increase, with concomitant increase in the damage of the gastric mucosa ( P <0.05), and there was a significant difference between the 6 and 24 hour groups and sham injury group( P <0.01). There was a pasitive correlation between the amount of bile acid in the stomach with the ulcer index ( r =0.55, P <0.01). Nowever, there were no significant differences in the content of bile acid in the blood and pH value in the stomach between injury and sham injury groups, neither did they show a correlation with the ulcer index. Conclusion Bile reflux might play an important role in the pathogenesis of stress ulcer after acute brain trauma. There was a positive correlation between the extent of bile reflux and gastric mucosa damage.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2004年第9期771-772,共2页
Medical Journal of Chinese People's Liberation Army
