摘要
目的 了解老年机械通气患者嗜麦芽窄食单胞菌 (SMA)感染及其药敏分析。方法 对 2 0 0 0年 1月～ 2 0 0 3年 12月机械通气患者分离出 5 7株 SMA致病菌的药物敏感试验进行分析。结果 全部患者均使用过广谱抗菌药物 ,其中 82 .5 %患者曾接受气管插管 ;药敏结果显示 :SMA对亚胺培南高度耐药 ;对第一、二代头孢菌素大多耐药 ;对环丙沙星、复方磺胺甲恶唑有较高的体外敏感性 ,分别为 87.7%和 80 .7%。结论 SMA感染的发生与严重的基础疾病、免疫功能低下、侵入性操作、广谱抗菌药物的应用密切相关 ;SMA对多种抗菌药物耐药 ,但是环丙沙星、复方磺胺甲恶唑对 SMA体外呈现较好的抗菌活性 ,可以作为临床治疗 SMA感染的有效抗菌药物。
Objective To further understand the reasons of the infection induced by Stenotrophomonas maltophilia (SMA) among elder mechanical-ventilation-use patients.Methods The participants of the study were mechanical-ventilation-use elder patients who had been with the hospital between January 2000 and December 2003. A total of 57 strains of SMA were tested for the drug sensitivity. Results All patients had experience of using broad-spectrum antibiotics and 82.5% of the patients were using tracheal cannula and tracheotomy, the primary risk factor was related to S. maltophilia infection during their stay in the hospital. The drug sensitivity test results showed that S. maltophilia had the highest resistance to imipenen, most resistant to the first and second generations of cephalosporins. The results also indicated that S. maltophilia was sensitive to ciprofloxacin (87.7%) and trimethoprim-sulfamethoxazloe (80.7%).Conclusion SMA infection is closely related to patients' severe primary diseases, decreased immunological functions, long-term inappropriate use of broad-spectrum antibiotics and invasive operations. S. maltophilia is multi-drug resistant, but iprofloxacin and trimethoprim-sulfamethoxazloe are effective against S. maltophilia infection.
出处
《临床肺科杂志》
2004年第6期640-642,共3页
Journal of Clinical Pulmonary Medicine
