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内皮素对眼部效应的研究进展 被引量：3

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摘要 内皮素及其受体广泛存在于眼组织中。内皮素除具有调节眼部血液循环作用外,还与 眼压、青光眼视神经损害及糖尿病性视网膜病变密切相关。此外,内皮素还具有促进角膜上皮细胞和 内皮细胞的再生修复等生物学效应。
作者 叶向彧 盛耀华
机构地区 上海第二医科大学附属新华医院眼科
出处 《国外医学（眼科学分册）》 2004年第4期220-223,共4页 Foreign Medical Sciences(Section of Ophthalmology )
关键词 内皮素 眼部 角膜上皮细胞 眼组织 视神经损害 研究进展 眼压 生物学效应
分类号 R77 [医药卫生—眼科]
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参考文献29

  • 1Fernandez-Durango R, Rollin R, Mediero A, et al. Localization of endothelin-1 mRNA expression and immunoreactivity in the anterior segment of human eye: expression of ETA and ETB receptors. Mol Vis, 2003, 9:103-109.
  • 2Hollo G, Visontai Z,Lakatos P,et al. Unoprostone isopropyl pretreatment decreases endothelin-1 release and the intra-ocular pressure spike induced by laser trabeculoplasty in the rabbit. Ophthalmologica, 2003, 217(3):231-236.
  • 3Yokota T, MARC, Park JY, et al. Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes. Diabetes,2003, 52(3) :838-845.
  • 4Evans T, Deng DX, Chen S, et al. Endothelin receptor blockade prevents augmented extracellular matrix component mRNA expression and capillary basement membrane thickening in the retina of diabetic and galactose-fed rats. Diabetes,2000, 49(4):662-666.
  • 5Chen S, Khan ZA, Cukiemik M, et al. Differential activation of NF-kappa B and AP-1 in increased fibronectin synthesis in target organs of diabetic complications. Am J Physiol Endocrinol Metab,2003, 284(6):E1089-1097.
  • 6Ripodas A, de Juan JA, Roldan-Pallares M, et al. Localisation of endothelin-1 mRNA expression and immunoresctivity in the retina and optic nerve from human and porcine eye. Evidence for endothelin-1 expression in astrocytes. Brain Res, 2001, 912(2) :137-1
  • 7Tao W, Prasanna G, Dimitrijevich S, et al. Endothelin receptor A is expressed and mediates the [Ca2+ ]i mobilization of cells in human ciliary smooth muscle, ciliary non-pigmented epithelium, and trabecular meshwork. Curr Eye Res, 1998, 17(1) :31-38.
  • 8Prasanna G, Krishnamoorthy R, Clark AF, et al. Human optic nerve head astrocytes as a target for endothelin-1. Invest Ophthalmol Vis Sci, 2002, 43(8) :2704-2713.
  • 9Stitt AW, Chakravarthy U, Gardiner TA, et al. Endothelin-like immunoreactivity and receptor binding in the choroid and retina.Curr Eye Res, 1996, 15(1): 111-117.
  • 10Wiederholt M, Bielka S, Schweig F, et al. Regulation of outflow rate and resistance in the perfused anterior segment of the bovine eye. Exp Eye Res, 1995, 61(2):223-234.

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国外医学（眼科学分册）
2004年 第4期

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