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^(13)C-美沙西丁呼气试验对肝硬化患者临床价值分析

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摘要 目的:探讨13C-美沙西丁呼气试验对肝硬化患者的临床应用价值. 方法:肝硬化患者42例和正常人31名,进行13C-美沙西丁呼气试验肝功能与临床Child-Pugh分级,进行比较并随访6 mo. 结果:正常人、肝硬化病理性肝损害期、Child A、B及C级的Mvmax40值(0.94±0.31%,0.64±0.04%, 0.36±0.07%,0.23±0.04%,0.08±0.04%)、Cum40 值(0.98±0.25,0.7±0.08,0.38±0.12,0.19±0.04, 0.08±0.05)及Cum120值(0.87±0.19,0.6±0.18, 0.49±0.13,0.29±0.08,0.09±0.03)均呈下降趋势, 各组间3类值差异均有统计学意义(P<0.05或P<0.01).肝硬化患者13C-美沙西丁呼气试验肝功能分级与临床Child- Pugh分级结果相比较,差别无统计学意义(P>0.05).随访过程中,1例13C-美沙西丁呼气试验肝功能分级为Child B级、临床分级Child-Pugh C级患者死于感染性休克; 4例13C-美沙西丁呼气试验肝功能分级和临床分级均为Child C级患者死于肝昏迷和上消化道出血. 结论:13C-美沙西丁呼气试验法是一种有效的肝硬化肝功能分级方法,有助于预后判断.
出处 《世界华人消化杂志》 CAS 2004年第8期1995-1997,共3页 World Chinese Journal of Digestology
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