摘要
目的 :为临床合理化使用免疫抑制剂他克莫司 (FK5 0 6 )提供理论依据 ,建立适合中国人肝脏移植受者FK5 0 6的有效血药浓度范围。方法 :用VISUALBASIC 6 .0开发程序 ;程序对用微粒子酶免分析法 (MEIA)测定全血FK5 0 6的血药浓度数据进行处理。结果 :肝脏移植术后 1mo内FK5 0 6理想有效血药浓度范围为 7～ 14 μg·L-1。结论 :该程序是开展治疗药物监测工作非常实用的工具 ,按程序所推荐浓度范围调整给药方案 ,既可获得满意的免疫抑制效果 ,又能减少排斥反应和FK5 0
AIM: To establish effective blood drug concentration range of tacrolimuns for Chinese liver transplantation recipients, in order to provide theoretical basis for reasonable use of the immuneosuppressive agent, tacrolimus. METHODS: The program was developed by VISUAL BASIC 6.0. The data of blood drug concentration, determinated by MEIA, was processed by the program. RESULTS: The effective blood drug concentration range of the patients in the first month of their liver transplantation was 7-14 μg·L -1. CONCLUSION: The program was a very applied tool to carry out blood drug concentration monitoring .The medication project adjusted by this reference concentration range of tacrolimus can achieve the satisfied immuneosuppressive result, and reduce rejection and tacrolimus toxicity.
出处
《中国临床药学杂志》
CAS
2004年第5期284-287,共4页
Chinese Journal of Clinical Pharmacy
基金
深圳市科技局基金资助项目 (编号 :2 0 0 0 0 60 17
2 0 0 2 0 40 48)
