摘要
目的 以曲马多为对照药物对各类颌面外科术后患者应用氯诺昔康行病人自控静脉镇痛(PCIA)的有效性和安全性进行评价。方法 将60例成年ASAⅠ～Ⅱ级行择期颌面外科手术患者,随机分为3组,曲马多(T)组:曲马多16 mg·kg-1;氯诺昔康(L)组:氯诺昔康1.3 mg·kg-1;曲马多和氯诺昔康(T+L)组:曲马多8 mg·kg-1+氯诺昔康0.65 mg·kg-1,均稀释至100mL,以2 mL·h-1行PCIA。记录3组在置泵后2、4、8、12、24、48 h的视觉模拟评分值(VAS)、患者对镇痛治疗总体印象评分及在各时间段中的不良反应。结果 T组、L组、T+L组48 h内各时间点VAS和PCIA结束后镇痛治疗总体印象评分无显著性差异(P>0.05),T组、L组、T+L组恶心呕吐发生率分别为33.3％、20.0％和6.67％,其中T+L组明显低于T组(P<0.05)。结论 采用氯诺昔康对颌面外科手术后病人自控镇痛安全有效,和曲马多复合使用能减少各自不良反应,可作为术后平衡镇痛的药物组成。
OBJECTIVE To evaluate the analgesic efficiency and safety of patient-controlled intravenous analgesia (PCIA) with lornoxicam and tramadol in patients undergoing the operation in the cranio-cervical region. METHODS Sixty ASA Ⅰ-Ⅲ adult patients, who undertook the operation in the cranio-cervical region were divided into 3 groups randomly, with 20 in each group. Tramadol Group (T Group): tramadol 16 mg·kg-1; Lornoxicam Group (L Group): lornoxicam 1. 3 mg·kg-1; Tramadol with lornoxicam Group (T + L Group): tramadol 8 mg·kg-1 + lor-noxicam 0. 65 mg·kg-1. The drugs in the three groups were diluted into 100 mL, background 2 mL·h-1, which lockout time 15 min, PCIA bolus 0. 5 mL. The efficiency of analgesia provided by PCIA was assessed by: (1) Visual analogue scale (VAS) at 2, 4, 8, 12, 24 and 48 h after the operation; (2) Patient's evaluation of the efficiency of PCIA obtained; (3) Side effects such as nausea and vomiting, dizziness, respiratory depression. RESULTS There was no statistically significant difference among the three groups in VAS and in the patient's evaluation of the efficiency of PCIA (P>0. 05). The (T+L) group caused fewer side-effects than the other two groups (P<0.05). CONCLUSIONS When used in patient-controlled intravenous analgesia, lornoxicam may provide a safe and efficient condition, and it can decrease the side-effects of each other when used together with tramadol, especially nausea and vomit. So it can be an essential component in balancing postoperation analgesia.
出处
《中南药学》
CAS
2004年第5期311-313,共3页
Central South Pharmacy
