摘要
目的 :观察阿魏酸钠治疗慢性肾小球肾炎的疗效。方法 :将 5 6例慢性肾小球肾炎患者随机分为治疗组 30例 ,应用阿魏酸钠治疗 ,对照组 2 6例应用肌苷及维生素B6。 2 1天后评价疗效。结果 :两组疗效、症状消失时间 (除血尿外 )、血浆比黏度、2 4h尿蛋白定量、内生肌酐清除率 (Ccr)和血肌酐 (Scr)差异均有显著性 (P <0 .0 5～P <0 .0 1)。结论 :阿魏酸钠可改善血液高凝状态 ,减少蛋白尿 ,降低血压 ,减少血管内皮损伤 ,改善慢性肾小球肾炎预后 。
Objective:To observe the effect of sodium ferulate in treatment of chronic glomerulonephritis.Methods:Fifty-six cases of chronic glomerulonephritis were randomly divided into treatment group(30 cases) and control group(26 cases).The treatment group were administered sodium ferulate and the controls received guttae intravenously and vitamin B 6.The curative effect was evaluated after 21 days.Results:There was significant difference between the two groups in the time of symptom disappearing,the plasma contrast viscosity,24 h urine protein quantization and creatinine clearance rate(Ccr) and serum creatinine(Scr)(P<0.05 to P< 0.01).Conclusions:Sodium ferulate can improve the blood hypercoagulation state; reduce the content of urine protein,lower the blood pressure and minimize the injury of vascular endothelium.It may protect the renal function to a certain extent and improve the prognosis of chronic glomerulonephritis.
出处
《蚌埠医学院学报》
CAS
2004年第6期510-511,共2页
Journal of Bengbu Medical College
关键词
肾小球肾炎
阿魏酸钠
内皮素
glomerulonephritis
sodium ferulate
endothelin
