摘要
目的 :探讨高原地区酒精性肝病患者血清一氧化氮 (NO)、白细胞介素 - 6 (IL - 6 )和肿瘤坏死因子 (TNF -α)的变化及其临床意义。方法 :采用放射免疫法和酶联免疫吸附法检测高原地区 4 8例酒精性肝病三个不同时期 [酒精性脂肪肝 (AF)、酒精性肝炎 (AH)和酒精性肝硬化 (AC) ]患者血清NO、IL - 6和TNF -α的水平。结果 :AH患者血清TNF -α和IL - 6浓度高于AF和AC患者 (P <0 .0 5 ) ;AC患者血清NO、IL - 6和TNF -α浓度均高于对照组 (P <0 .0 5 )。结论 :NO、IL - 6和TNF -α在高原AF、AH和AC的发展过程中起重要作用 。
Objective: To investigate the changes of serum of nitric oxide(NO),interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α) in patients with high altitude alcoholic liver disease(ALD)and their clinical significances. Methods: The levels of serum NO,IL-6 and TNF-α were measured by radioimmunoassay and enzyme-linked immunosorbent assay(ELISA)in patients with ALD including 21 alcoholic fatty liver(AFL)patients,9 alcoholic hepatitis(AH),18 alcoholic cirrhosis(AC)and 40 healthy control groups. Results: The levels of serum NO,IL-6 and TNF-α in AC patients were significantly higher than those in normal controls(P<0.05). IL-6 and TNF-α in AH patients were significantly higher than those in AF and AC patients(P<0.05).Conclusion:The increased levels of serum NO,IL-6 and TNF-α have important roles in the development of ALD from AF to AH and AC.
出处
《中国临床医学》
2004年第4期496-497,共2页
Chinese Journal of Clinical Medicine
