摘要
5-烃基-2,3-二甲基吡嗪-1-N-氧化物与三氯氧磷在回流温度下反应制得6种2-氯-3-烃基-5,6-二甲基吡嗪,产率71～82%。由2-氯-3-异丙基-5,6-二甲基吡嗪与烷醇钠反应得4种相应的烷氧基取代吡嗪,产率20.3～70.3%。由固-液相转移催化2-氯-3-异丙基(或苄基)-5,6-二甲基吡嗪与硫醇反应得4种相应的烷硫基取代吡嗪,产率47.5～68%。合成化合物的结构经元素分析和 IR、~1HNMR、MS 谱测定与预期结构相符。
Reaction of 5-alkyl-2,3-dimethylpyra-
zinc-1-N-oxides with phosphoryl chloride
under reflux gave six 2-chloro-3-alkyl-
5,6-dimethylpyrazines with good yields(71%～
82%),among which five are new compounds.
Alkoxylation of 2-chloro-3-isopropyl-5,6-
dimethylpyrazine in R'ONa-R'OH under
reflux gave four corresponding 2-alkoxy-
3-isopropyl-5,6-dimethylpyrazines with
yields of 20.3%～70.3%.Four 2-alkylthio-3-
isopropyl (or benzyl)-5,6-dime thylpyrazines
were obtained from the alkylthiolation of 2-
chloro-3-isopropyl(or benzyl)-5,6-dime-
thylpyrazines with R^2SH under solid-liquid
phase transfer catalytic conditions with satis-
factory yields(47.5%～68%),all of which are
new compounds.Their structures were con-
firmed by elemental analysis,IR,~1HNMR and
MS spectrometry.
出处
《化学试剂》
CAS
CSCD
北大核心
1993年第6期329-331,342,共4页
Chemical Reagents
关键词
氯
烃基
二甲基吡嗪
烷氧基化
2-chloro-3-alkyl-5
6-dimethyl-pyrazine
synthesis
alkoxylation
alkylthiolation
