摘要
目的 观察 12 5mg米非司酮用于紧急避孕的临床效果及对月经的影响。方法 采用开放性随机对照的试验方法 ,按研究方案对单次无防护性交 72h内要求紧急避孕的 12 0 0例妇女 ,随机分为观察组 (n =6 0 0 )和对照组 (n =6 0 0 ) ,观察组妇女单次口服 12 5mg米非司酮 ;对照组妇女单次口服 2 5mg米非司酮。服药后嘱两组妇女按期检查直至月经来潮 ,并观察其避孕效果、副作用及对月经的影响。结果 采用经典Dixon方法计算 ,两组妇女各有 6例妊娠 ,观察组避孕有效率为 89 11% ,对照组为 88 5 9% ,两组避孕效果间差别无显著性意义 (P >0 0 5 ) ,两组的副作用均较轻。结论 12 5mg米非司酮用于紧急避孕时与 2 5mg的疗效是等效的 ,并具有避孕效果好、无明显副作用。
Objective To observe the contraceptive efficacy,side effects,influences on menstruation and acceptability of mifepristone in small doses of 12.5 mg,comparing with 25.0 mg.Methods By using randomised controlled methods,1200 women with unprotected intercourse within 72 hours were enrolled into groups,GroupⅠand GroupⅡ.In GroupⅠ(n=600),patients were given mifepristone in a single dose of 12.5 mg.In Group Ⅱ (n=600),patients were given 25 mg mifepristion.Both two groups patients′were told to receive follow-up survey on time,including their contraceptive efficacy,side effects andchanges of menstruation.Results There were six megnacies occurred in each group.According the classic methods of Dixon,the effective rate of contraception was 88.59% in GroupⅠand 89.11% in Group Ⅱ.There were no significant differences between the two groups (P>0.05).There were no adverse reaction occurred.Conclusion Mifepristone in a single.dose of 12.5 mg for emergency contraception has the same effect as 25 mg,with the advantages of effective contraception,no obvious adverse reaction,and slight effect on menstruation.
出处
《中国全科医学》
CAS
CSCD
2004年第20期1477-1478,共2页
Chinese General Practice
