摘要
目的 为组织工程化口腔黏膜的培养筛选合适的载体材料。方法 在兔皮下手术埋入8种不同组分的聚乳酸羟基乙酸(PLCA),手术后第1、2、3、4周取出,分别观察其质量变化和周围组织反应情况。结果PLGA I、Ⅱ、Ⅲ分别在术后第2、3、4周时全部降解吸收,其余组PLGA在4周时仅降解50％左右;组织学观察,PLGA I、Ⅱ、Ⅲ在动物体内反应符合一般生物相容性材料的组织反应过程。结论 PLGAⅡ降解速度符合临床需要,且其具有良好的组织相容性,可用作口腔黏膜组织工程载体材料。
Objective To look for the best carrier for cultivating oral tissue engineered mucosa. Methods A series of membrane of scaffold materials of polycleclide-co-plycoclide(PLGA) were studied on their weight and biocompatibility after they had been implanted subcutaneously in rabbits for 1,2,3,4 weeks respectively. Results PLGA I , Ⅱ , Ⅲ degraded completely in rabbits after 2,3,4 weeks respectively. The other PLGA membrane degraded about 50% after 4 weeks. Histologically, the reactions of PLGAⅠ ,Ⅱ ,Ⅲ with surrounding tissues were normal and membranes had a good biocompatibility. Conclusion The biode-grading rate of PLGA Ⅱ is suitable for clinic practice. PLGA Ⅱ was a promising carrier for oral tissue-engineered mucosa due to its excellent biocompatibility and biodegrading rate.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
2004年第5期362-365,共4页
West China Journal of Stomatology
基金
江苏省教育厅自然科学基金资助项目(03KJD3201)
