摘要
目的探讨川芎嗪对阿霉素肾损伤的保护作用 ,并与复方丹参组对照。方法成年健康大鼠 6 0只 ,随机分为 5组 :正常对照组 (A组 ) ,模型组 (B组 ) ,川芎嗪治疗C1组 (C1组 ,0 .2g·kg-1·d-1) ,川芎嗪治疗C2 组 (C2 组 ,0 .4g·kg-1·d-1) ,复方丹参治疗组 (D组 )。一次性尾静脉注射阿霉素 6 .5mg·kg-1制备阿霉素肾病变模型。测定不同处理后第 7天、14天的尿蛋白排泄量 ,第 14天的血清SOD、MDA及第 14天血液生化指标 ,同时取肾组织标本观察病理学改变。结果处理后的尿蛋白排泄量低于模型组 ,血TG、CHOL改善明显 (P <0 .0 1) ,血BUN有所改善(p <0 .0 5 ) ,血SOD上升和MDA下降 (p <0 .0 5 ) ,病理检查发现水肿减轻 ,肾小球和肾小管明显修复 ,与丹参组无明显差异 (p >0 .0 5 )。结论川芎嗪能缓解肾小球和肾小管的损伤 ,提高血SOD的活性 ,具有肾保护作用。
Objective To explore the protective effects of ligustrazine on adriamycin-induced nephrosis in rats,and compare it with that of Fufangdanshen injection.Methods 60 adult wistar rats were randomly divided into five groups, normal group,model group, ligustrazine group C 1 (0.2g·kg -1 ·d -1 ) and C 2 (0.4g·kg -1 ·d -1 ) ,and Fufang danshen group.The models of adriamycin-induced nephrosis were established by intraveno usly injecting doxorubicin hydrochloride 6.5mg·kg -1 .Proteinuria of 7th day,14th day ,BUN,Scr,TG,CHOL,SOD,MDA of 14th day were measured,and renal pathologic changes were examined. Results Compared with the model group, the proteinuria,TG,CHOL,MDA in ligustrazine group rats were decreasedsignificant(p<0.01), BUN also were decreased(p<0.05), the activity of SOD were increased ,pathological obseravition showed the glomerulus and urinitubule were obviously improved, too .The above index in ligustrazine group had no obvious difference with the rats in Fufangdanshen group.Conclusion ligustrazine can improve the activity of SOD,repair the glomerulus and urinitubule.These results indicate that ligustrazine can protect adriamycin-induced nephrosisin rats.
出处
《咸宁学院学报（医学版）》
2004年第5期326-329,共4页
Journal of Xianning Univarsity(medical Sciences)
