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肺动脉高压的发病机制及治疗进展 被引量:12

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摘要 肺动脉高压可由许多心、肺和肺血管疾病引起。引起肺动脉高压的原因很多 ,而原发性肺动脉高压是其中的一个特殊的类型。目前 ,关于肺动脉高压的发病机制仍不十分清楚 ,但体内舒张与收缩血管物质的不平衡是发病的主要因素。随着对发病机理的认识 ,治疗观点已从传统的扩张血管治疗过渡到调整体内舒缩血管物质的平衡。
作者 杨媛华 王辰
出处 《国外医学(呼吸系统分册)》 2004年第5期323-325,共3页 Section of Respiratory System Foreign Medical Sciences
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参考文献19

  • 1Galié N,Humbert M,Wachiery JL,et al.Effects of beraprost sodium,an oral prostacyclin analogue,in patients with pulmonary arterial hypertension:a randomized,double-blind,placebo-controlled trial.J Am Coll Cardiol,2002,39:1496-1502.
  • 2Galiè N,Hinderliter AL,Torbicki A,et al.Effects of the oral endothelin receptor antagonist bosentan on echocardiographic and Doppler measures in patients with pulmonary arterial hypertension.American Congress of Cardiology Atlanta,2002.17-20.
  • 3Taraseviciene-Stewart L,Kasahara Y,Alger L,et al.Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension.FASEB J,2001,15:427-438.
  • 4Hypertension Michelakis ED,Tymchak W,Noga M,et al.Long-term treatment with oral sildenafil is safe and improves functional capacity and hemodynamics in patients with pulmonary arterial.Circulation,2003,108:2066-2069.
  • 5Voelkel NF,Tuder RM,Wade K,et al.Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats.J Clin Invest,1996,97:2491-2498.
  • 6Massague J,Blain SW,Lo RS.TGF- signalling in growth control,cancer,and heritable disorders.Cell,2000,103:295-309.
  • 7Gaine SP,Rubin LJ.Primary pulmonary hypertension.Lancet,1998,352:719-725.
  • 8Wright L,Tuder RM,Wang J,et al.5-Lipoxygenase and 5-lipoxygenase activating protein (FLAP) immunoreactivity in lungs from patients with primary pulmonary hypertension.Am J Respir Crit Care Med,1998,157:219-229.
  • 9Simmoneau G,Barst R,Galie N,et al.Continuous subcutaneous infusion of treprostinil,a prostacyclin analogue,in patients with pulmonary arterial hypertension.Am J Respit Crit Care Med,2002,165:800-804.
  • 10Fruhwald FM,Kjellstrom B,Perthold W,et al.Continuous hemodynamic monitoring in pulmonary hypertensive patients treated with inhaled iloprost.Chest,2003,124:351-359.

二级参考文献11

  • 1Semenza GL,Wang GL. A nuclear factor induced by hypoxia via de novo protein s y nthesis binds to the human erythropoietin gene enhancer at a site required for t ranscriptional activation. Mol Cell Biol,1992,12: 5447-5454.
  • 2Palmer LA, Semenza GL, Stoler MH, et al. Hypoxia induces ty pe II NOS gene exp ression in pulmonry artery endothlial cells via HIF-1. Am J Physiol, 1998, 274 (2 Pt 1): L212-L219.
  • 3Hartsfield CL, Alam J, Chio AM. Differential signaling pathw ays of HO-1 gene e xpression in pulmonary and systemic vascular cells. Am J Physiol, 1999, 277(6 P t 1): L1133-L1141.
  • 4Hu J, Discher DJ, Bishopric NH, et al. Hypoxia regulates ex pression of the en dothelin-1 gene through a proximal hypxia-inducible factor-1 binding site on the antisense strand. Biochm Biophys Res Commun, 1998, 245: 894-899.
  • 5Horio T, Kohno M, Yokokawa K, et al. Effect of hypoxia on p lasma immunoreacti ve endothelin-1 concentration in anesthetized rats. Metabolism, 1991, 40: 999 -1001.
  • 6Chen SJ, Chen YF, Opgenorth TJ, et al. The orally active non peptide endothelin A-receptor antagonist A-127722 prevents and reverses hypoxia-induced pulmona ry hypertension and pulmonary vascular remodeling in Sprague-Dawley rats. J Cardi ovasc Pharmacol, 1997, 29: 713-725.
  • 7Givertz MM, Colucci WS, LeJemtel TH, et al. Acute endothelin A receptor blocka de causes selective pulmonary vasodilation in patients with chronic heart failur e. Circulation, 2000,101: 2922-2927.
  • 8Jean-Francois J, Lucas M, Cernacek P, et al. Effectiveness of a nonselective ETA/B and a selective ETA antagonist in rats with monocrotalin induced pulmonary hypertension. Circulation, 2001, 103:314-3 18.
  • 9Yu AY, Frid MG, Shimoda LA, et al.Temporal, spatial,and oxyg en-regulated expre ssion of hypoxia-inducible factor-1 in the lung. Am J Physiol, 1998, 275(4 Pt 1): L818-L826.
  • 10Riddle SR, Ahmad A, Ahmad S, et al. Hypoxia induces hexokinase II gen e expression in human lung cell line A549. Am J Physiol, 2000, 278: L407-L416.

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