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促血管生成素-1与血管通透性调节 被引量：9

Angiopoietin-1 and regulation of vascular permeability
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摘要 Angiopoietin-1 (Ang-1) is a newly-found endothelium-specific proangiogenic factor and it had been proved essential roles in both vasculogenesis and angiogensis. Among them, its anti-leakage ability may have great potential applications in clinical treatment of vascular hyper-permeability in a variety of diseases such as cancer, diabetic retinopathy, rheumatoid arthritis, asthma. In this review, some research progresses focused on this aspect are discussed. [ Angiopoietin-1 (Ang-1) is a newly-found endothelium-specific proangiogenic factor and it had been proved essential roles in both vasculogenesis and angiogensis. Among them, its anti-leakage ability may have great potential applications in clinical treatment of vascular hyper-permeability in a variety of diseases such as cancer, diabetic retinopathy, rheumatoid arthritis, asthma. In this review, some research progresses focused on this aspect are discussed. [
作者 乐飞 金惠铭
机构地区 复旦大学上海医学院生理与病理生理学系
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2004年第10期1929-1932,共4页 Chinese Journal of Pathophysiology
关键词 血管生成素 内皮细胞 毛细血管通透性'…1 . . . . 一 一 一 一 Angiopoietin Endothelial cells Capillary permeability
分类号 R363 [医药卫生—病理学]
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参考文献24

  • 1Bates DO, Hillman NJ, Williams B, et al. Regulation of microvascular permeability by vascular endothelial growth factor[J]. J Anat, 2002, 200(6):581-597.
  • 2Epstein SE, Kornowski R, Fuchs S, et al. Angiogenesis therapy amidst the hype, the neglected potential for serious side effects[J]. Circulation, 2001,104(1):115-119.
  • 3Davis S, Aldrich TH, Jones PF, et al. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning[J]. Cell, 1996, 87(7):1161-1169.
  • 4Maisonpierre PC, Surl C, Jones PF, et al. Angiopoietin-2, a natural antagonist for TIE2 that disrupts in vivo angiogenesis[J]. Science, 1997, 277(5322): 55-60.
  • 5Valenzuela DM, Griffiths JA, Rojas J, et al. Angiopoietin 3 and 4: diverging gene counterparts in mice and humans[J]. Proc Natl Acad Sci USA, 1999, 96(5):1904-1909.
  • 6Grosios K, Leek JP, Markham AF, et al. Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3-q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping[J]. Cytogenet Cel
  • 7Loughna S, Sato TN. Angiopoietin and TIE signaling pathway in vascular development[J]. Matrix Biol, 2001,20(5-6):319-325.
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  • 9Suri C, Jones PF, Patan S, et al. Requite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis[J]. Cell, 1996, 87(7):1171-1180.
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二级参考文献28

  • 1[1]Davis S, Aldrich TH, Jones PF, et al. Isolation of angiopoietin-1, a ligand for the tie2 receptor by secretion-trap expression cloning[J]. Cell, 1996, 87(7):1161-1169.
  • 2[2]Procopio WN, Paul IP, Lee WMF, et al. Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity[J]. J Biol Chem, 1999,274(42): 30196-30201.
  • 3[3]Huang YQ, Li JJ, Karpatkin S. Identification of a family of alternatively spliced mRNA species of angiopoietin-1[J]. Blood, 2000,95(6): 1993-1999.
  • 4[4]Suri C, Jones PF, Patan S, et al. Requisite role of angiopoietin-1, a ligand for the tie2 receptor, during embryonic angiogenesis[J]. Cell, 1996, 87(7):1171-1180.
  • 5[5]Maisonpierre PC, Suri C, Jones PF, et al. Angiopoietin-2, a natural antagonist for tie2 that disrupt in vivo angiogenesis[J]. Science, 1997, 277(5322):55-60.
  • 6[6]Nishimura M, Miki T, Yashima R, et al. Angiopoietin-3, a novel member of the angiopoietin family[J]. FEBS, 1999,448(3):254-256.
  • 7[7]Valenzuela DM, Griffiths JA, Rojas J, et al. Angiopoietin-3 and 4: diverging gene counterparts in mice and humans[J]. Proc Natl Acad Sci USA, 1999,96(5):1904-1909.
  • 8[8]Suri C, McClain J, Thurston G, et al. Increased vascularization in mice overexpressing angiopoietin-1[J]. Science, 1998,282(5388):468-471.
  • 9[9]Risau W. Mechanisms of angiogenesis[J]. Nature, 1997, 386(6626):671-674.
  • 10[10]Carmellet P, Ferrelra V, Breler B, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele[J]. Nature, 1996,380(6573):435-439.

共引文献51

同被引文献106

引证文献9

二级引证文献34

中国病理生理杂志
2004年 第10期

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