摘要
目的:探讨西藏高原拉萨地区居民长期饮酒与肝纤维化之间的关系. 方法:选择在拉萨地区长期生活的酗酒者50例(研究组)和从未有饮酒的20例(对照组).联合检查其肝功、凝血酶原、B超、CT及血清细胞外基质,判断长期饮酒与肝纤维化之间的相关性. 结果:研究组中,50例酗酒者有舌边淤血、牙龈萎缩、巩膜黄染、毛细血管扩张等体内维生素、微量元素和胆红素代谢功能障碍等体征.超声检查后研究组与对照组对比结果,肝左叶大小差异显著(6.60±1.14 vs 5.89±0.91, P<0.01),肝脏回声、肝内血管显示度有显著性差异(56.0% vs 1.1%,P<0.05),GGT,AST有显著性差异(2863±1513 vs 1119±644,993±704 vs 518±271,P<0.01), ALT,TBiL,DBiL有显著性差异(1132±970 vs 744±502,20.5±10.7 vs 18.0±6.0,5,8±5.6 vs 4.9±2.9, P<0.05).IV,HA有显著性差异(155±109 vs 87±46, 210±141 vs 92±54.P<0.01). 结论:西藏高原长期饮酒者均有不同程度的肝功能的损坏, 肝脏结构的变化以及肝纤维化.饮酒量、酒龄与肝细胞损害呈正比,B超和血清生物化学检查对早期诊断治疗有重要作用.
AIM. To study the relationship between hepatic fibrosis and long-term alcoholism of residents in Lhasa area. METHODS: Fifty individuals with more than 5-year alcoholic history in Lhasa area were involved in the study and 20 without alcoholic history were as control. Associated examinations consisting of liver functions, serum HbsAg, extracellular matrix (ECM) components (type IV collagen and hyaluronic acid, HA) and type B ultrasonic for hepatocholecystic system and spleen were used to assess the liver status. RESULTS: Fifty individuals in the study group represented symptoms such as congestion of tongue edge, gingival atrophy, icteric sclera, telangiectasis. Ultrasonic examinations showed that the size of left hepatic lobe in the study group was significantly different from that in the control group (6.60 ± 1.14 vs 5.89 ± 0.91, P<0.01). The liver structure, portal vein diameter and liver blood vessels were also showing significant differences (56.0% vs 1.1%, P <0.05), The indexes of liver function such as GGT, AST (2 863 ± 1513 vs 1119 ± 644, 993 ± 704 vs 518 ± 271, P<0.01), ALT, TB, DbiL (1 132 ± 970 vs744 ± 502, 20.5 ± 10.7 vs 18.0 ± 6.0, 5.8 ± 5.6 vs 4.9 ± 2.9,P<0.05) manifested significant differences between the study group and the control group. ECM IV and HA in the study group also showed prominent differences from those in the controls (155 ± 109 vs 87 ± 46, 210 ± 141 vs 92 ± 54, P<0.01). CONCLUSION: Different degree of liver damage, hepatic structure changes and hepatic fibrosis appear in individuals with long-term alcoholism in Lhasa area. Hepatocellular damage is directly related to the volume of alcohol incepted and duration of alcoholic history. B-ultrasonography and serum biochemistry should be adopted for early diagnosis.
出处
《世界华人消化杂志》
CAS
2004年第9期2140-2142,共3页
World Chinese Journal of Digestology
