摘要
目的研究溶剂分散法改善小剂量难溶性药物的溶出均一性。方法采用溶剂分散法制备含小剂量难溶性药物格列苯脲的复方盐酸二甲双胍胶囊 ,与采用格列苯脲微粉化法制备的胶囊进行溶出均一性比较 ,。
To compare the dissolution uniformity of glibenclamide in compound metformin hydrochloride capsules prepared with solvent dispersing method using microcrystallite as carrier to that prepared with micronization method. The result shows that the solvent dispersing method has an advantage over micronization method for dissolution uniformity of glibenclamide.
出处
《广东药学院学报》
CAS
2004年第5期464-465,477,共3页
Academic Journal of Guangdong College of Pharmacy
关键词
格列苯脲
溶剂分散法
微粉化技术
溶出均一性
glibenclamide
solvent dispersing method
dissolution uniformity
micronization method
