摘要
目的 了解某县成人经血感染艾滋病病毒(HIV)病例生存时间分布规律。方法 采用回顾性队列研究的方法,收集该县2002年底前确认的78例经血感染HIV病例的生存时间及其影响因素信息,使用Kaplan-Meier法描述生存分布,Cox比例风险模型分析影响因素。结果 78例感染者中位生存时间为7.40年,95％可信区间为6.79～8.02年。感染者总死亡率为78.57/1000人年,艾滋病(AIDS)相关死亡率为72.95/1000人年。感染时年龄在30～40岁组,1995年底以前感染组生存时间较长。结论 研究结果可能低估了该县经血感染HIV者生存时间,在HIV/AIDS估计和预测中应予以调整,生存时间还与感染年龄有关,对不同的感染年龄组采取不同的生存时间分布规律。
Objective To understand the survival rate of adult blood-borne human immunodeficiency virus(HIV)cases in a county. Methods A retrospective cohort study was carried out to determine the survival from HIV infection and related factors among 78 adult HIV cases infected by blood and confirmed by the end of 2002. Kaplan-meier method was used to describe the survival distribution and Cox proportional hazard model was used to determine the factors associated with the survival time. Results The total mortality after infection was 78.57/1000 p-y and AIDS related mortality was 72.95/1000 p-y. The median survival time was 7.40 years(95% Confidence Interval: 6.79-8.02). After adjustment for the clinical stage at presentation(HIV or AIDS), people who got infected at the age of 30-40 years or infected by the end of 1995 would proceed to death slower than the other groups. Conclusion The survival of HIV cases infected by blood at the county level might have been underestimated and should be adjusted when HIV/AIDS was estimated and projected. Survival was associated with age when infection started so different survival functions should be used on different age groups that infection started.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2004年第11期941-944,共4页
Chinese Journal of Epidemiology
