摘要
目的 探讨严重急性呼吸综合征 (SARS)患者病程中外周血象及肝功能的变化规律 ,以进一步认识 SARS的临床特征。方法 以 16 9例在太原市 5家医院住院治疗的 SARS患者作为研究对象 ,定期检验外周血象及肝功能。结果 疾病早期 (1d)多数患者 (90 .0 0 %以上 )白细胞计数正常或偏低 ,而于第 2～ 3周有4 0 .0 0 %患者白细胞增高 ,伴有中性粒细胞增高及淋巴细胞降低 ;约 4 .4 4 %～ 12 .76 %的患者可出现血小板降低。随着病程的进展 ,血红蛋白降低的患者从 4 .2 5 %增至 39.5 9% ;丙氨酸转氨酶和天冬氨酸转氨酶均增高 ,9～ 15 d达峰值 ;所有患者血清总蛋白始终正常 ,而 4 0 .35 %～ 72 .0 0 %的患者血清白蛋白降低。结论 SARS患者病程中可出现白细胞增高、血小板降低、血红蛋白降低及肝功能的异常 ,防治中应予以注意。
Objective To study peripheral blood picture and liver function of severe acute respiratory syndrome(SARS), and to accumulate more experience in prevention and treatment this syndrome. Methods The peripheral blood picture and liver function of 169 cases with SARS were analyzed. These patients were admitted to five hospitals in Taiyuan from March to May, 2003. Results Above 90 00% patients had normal or low white blood cell(WBC) count on the first day. From then on, during the second to third week, about 40 00% of the patients showed high WBC count〔average: (13 42±2 87)×10 9/L at 15 th day and (13 68±3 26)×10 9/L at 21 st day〕 and neutrophil(0 809±0 063 at 15 th day and 0 805±0 061 at 21 st day), and 21 97%-52 15% cases with low lymphocyte count(0 111±0 044-0 134±0 040). About 4 44%-12 76% of patients developed low platelet and 4 20%-33 33% of cases with low hemoglobin level . And 32 76%-62 50% of cases were found to have high alanine aminotransferase(above 40 U/L ), 13 04%-40 00% cases with high aspartate aminotransferase(above 40 U/L) and 40 35%- 72 00% cases with low albumin content. But serum total protein remained normal during the whole clinical course. Conclusion SARS cases may develop leucocytosis, low lymphocyte count, low platelet count, low hemoglobin level and abnormal liver function.
出处
《中国危重病急救医学》
CAS
CSCD
2004年第11期660-663,共4页
Chinese Critical Care Medicine
基金
山西省科委 SARS临床治疗研究攻关资助项目(0 3 2 0 0 46)
关键词
严重急性呼吸综合征
外周血象
肝功能
转氨酶类
severe acute respiratory syndrome
peripheral blood picture
liver function
aminotransferase
