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非接触二次色散法测量人体血糖的初步研究 被引量：1

Preliminary Investigation of Second-Order Dispersion for Noninvasively Measuring Glucose Concentration in Human Body
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摘要 提出了一种测量血糖浓度的新方法———二次色散法 ,此方法采用低相干干涉仪来测量时间相干干涉信号 ,通过傅里叶变换和多项式拟合获得二次色散。初步测量了三种不同浓度的糖溶液在 0 .5 5 μm到 0 .8μm之间的二次色散 ,实验结果发现随着血糖浓度的增加 ,二次色散也随之增加。研究证明该方法是一种潜在的无接触、无伤害在线探测人体血糖浓度的方法。为设计一种非接触、无伤害在线探测人体血糖浓度的光学医疗仪器奠定基础。最后讨论了采用本方法尚需改进的问题和进一步的工作。 A possibility to measure glucose concentration using a Michelson partial coherent interferometer (LCI) is presented. For three different glucose concentrations, 0.18 mg/mL (hypoglycemia), 0.95mg/mL (normal level) and 3.36 mg/mL (hyperglycemia) the second-order dispersion is investigated over the wavelength range 0.5 μm to 0.85 μm, and the investigation shows that different concentrations are associated with different second-order dispersions. The second-order dispersions for wavelengths from 0.55 μm to 0.8 μm are determined by Fourier analysis of the interferogram. This approach can be applied to measure the second-order dispersion for distinguishing the different glucose concentrations. It can be expected as a potentially noninvasive method to measure glucose concentration in human body.
作者 刘娟 简水生
机构地区 北京交通大学光波技术研究所
出处 《光学学报》 EI CAS CSCD 北大核心 2004年第10期1297-1300,共4页 Acta Optica Sinica
基金 国家自然科学基金 (30 30 0 0 80 ) 北京市自然科学基金资助课题
关键词 应用光学 医学信息处理 二次色散 低相干干涉仪 血糖浓度 applied optics medical information processing second-order dispersion low coherence interferometer glucose concentration
分类号 O436.1 [机械工程—光学工程] Q63 [生物学—生物物理学]
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参考文献18

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共引文献20

同被引文献11

  • 1BLANK T B, RUCHTI T L, MALIN S F, et al. The use of near-infrared reflectance for the non-invasive prediction of blood glucose levels [J]. IEEE Laser Electro-Optics Society Newsletter, 1999,13(5):9-12.
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二级引证文献16

光学学报
2004年 第10期

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