摘要
目的 :探讨羊踯躅根乙酸乙酯提取物的药理作用及急性毒性。方法 :采用小鼠热板法和扭体法试验研究其镇痛作用 ;对二甲苯所致小鼠耳部炎症的影响研究其抗炎作用。结果 :乙酸乙酯提取物灌胃给药的LD50 为 12 5 8.5mg·kg 1 ;对小鼠耳廓发炎肿胀无显著抗炎作用。对浅表性物理刺激 (如热板刺激 )抑制较强 ,而对腹腔注射醋酸引起的大面积且较持久的疼痛抑制作用不佳。结论 :乙酸乙酯提取物具有镇痛作用 ,但抗炎效果不强。
Objective:To probe into the pharmacological ac tions and acute toxicity of the ethyl acetate extract from the root of Rhodode ndron molle G. Don. Methods:The analgesic actions of the extract were studie d with the hot plate and writhing reflex test in the mouse. The anti-inflammato ry action of the substance was examined by observing its effect on ear swelling of the mouse induced by dimethylbenzene. Results:The LD 50 of the ethyl acetate extract admi nistered by gastrogavage was 1 258.5 mg·kg -1. No apparent anti-inflamma tory effect on the murine ear swelling was demonstrated following administration of the extract by gastrogavage for 3 consecutive days. The extract was shown to have a relatively strong analgesic effect on superficial pain induced by the ho t plate. However ,it had little analgesic action on the extensive and lasting de ep pain sensation caused by intraperitoneal injection of acetic acid as evidence d by the writhing reflex test . Conclusion:The ethyl acetate extract of the root of Rh ododendron molle G Don was shown to have a definite analgesic but only a weak anti-inflammatory effect.
出处
《医药导报》
CAS
2004年第12期893-895,共3页
Herald of Medicine
基金
湖北省政府专项拨款资助
关键词
羊踯躅根
乙酸乙酯提取物
镇痛
抗炎
急性毒性
Root of Rhododendron molle G. Don
Ethyl acetate
Analgesia
Anti-inflammation
Acute toxicity
