摘要
目的探讨华东地区汉族HLA-Ⅱ类基因与白癜风临床特征的相关性。方法采用聚合酶链反应-序列特异性寡核苷酸探针(PCR-SSOP)方法检测华东地区汉族白癜风患者HLA-DRB1、DQA1和DQB1位点的等位基因,使用SPSS10.0统计软件分析。结果HLA-DQA10103与伴发内分泌疾病的患者有显著正相关,DRB109与C4降低的患者明显负相关。按临床类型分析,发现局限型与DRB109和DQA103正相关,非节段型与DQA103正相关。结论:在华东地区汉族人群中,白癜风的临床特征与HLA-Ⅱ类基因有一定的相关性。
Objective: To investigate the association of clinical features with HLA class II genes in vitiligo among the Han nationality of East China. Methods: Ninety-eight patients with vitiligo and 150 healthy controls were studied for HLA-DRB1, DQA1 and DQB1 locus alleles by PCR-SSOP typing. All data were analysed by SPSS 10.0. Results: It was shown that, in the patients with vitiligo, there was positive correlation between DQAI*0103 and endocrine diseases, and DQB1*09, DQAI*03 and localized type skin lesion. But DRB1*09 was negatively correlated with the decrease of C4 in the patients with vitiligo. Conclusions: The results suggest that there are certain correlations between clinical features and HLA class II genes in vitiligo patients among the Han nationality of East China.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2003年第12期697-699,共3页
Journal of Clinical Dermatology
基金
中华医学会皮肤性病学分会皮肤科研究基金资助项目20030225
关键词
白癜风
HLA-Ⅱ类基因
Ⅱ临床特征
汉族
vitiligo
HLA class II genes
clinical feature
eastern Han Chinese
