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调节性T细胞在支气管哮喘中的重要作用 被引量：3

The important role of regulatory T cells in asthma
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摘要 本文论述了调节性T细胞的概念及几种主要的调节性T细胞 :Th1、Th2、Th3细胞、TR细胞、CD4 + CD2 5 + 细胞、NKT细胞的主要特点和研究现状。并论述了这几种调节性T细胞在支气管哮喘中的重要作用。提出Th1细胞更趋向于一种炎症细胞而非抗炎细胞 ,而其他各种调节性T细胞可能提供免疫保护及抗炎作用起到抑制哮喘发展的作用 ,通过控制调节性T细胞的治疗可能成为哮喘治疗的有效手段。 The article discusses the concept of regulatory T cells(T R ) and the main characteristic and research status of several main T R cells: Th1,Th2,Th3 cells, T R cells, CD4 +CD25 + cells,NKT cells, and dissertate the important role of these regulatory T cells in asthma.It was showed that Th1 cell are generally proimflamtory cell rather than anti-imflamtory cell, Rather, a wide variety of regulatory T cells could probably control the development of asthma by protective imunuity or anti-imflamaory response. Therapies that control the development of regulatory T cells in patients with asthma may be very effective in the prevention and cure of these disorders.
作者 许飞 林耀广
机构地区 中国协和医科大学北京协和医院
出处 《基础医学与临床》 CSCD 北大核心 2004年第4期371-374,共4页 Basic and Clinical Medicine
关键词 调节性T细胞 支气管哮喘 治疗 TH1细胞 TH2 炎症细胞 CD25^+ 发展 重要作用 趋向 regulatory T cells asthma
分类号 R562.25 [医药卫生—呼吸系统]
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参考文献10

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同被引文献32

  • 1许敏兰,陶芳标.儿童哮喘的全球流行及影响因素[J].国外医学（妇幼保健分册）,2005,16(3):161-163. 被引量：34
  • 2缪界萍,杨学文,张莉.发作期哮喘患者外周血T细胞亚群、B细胞和NK细胞的变化及临床意义[J].放射免疫学杂志,2006,19(6):521-522. 被引量：4
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  • 5Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains ( CD25 ). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol, 1995,155 :1151-1164.
  • 6BARNES P J. Pathophysiology of asthma [ J]. Br J Clin Pharmacol, 1996, 4: 3-10.
  • 7LICCARDI G, CUSTOVIC A, CAZZOLA M, et al. Avoidance of allergens and air pollutants in respiratory allergy[J]. Allergy, 2001, 56: 705-722.
  • 8MCCONNELL R, BERHANE K, GILLILAND F, et al. Air pollution and bronchitic symptoms in southern california children with asthma[ J]. Environ Health Perspect, 1999, 107(9): 757-760.
  • 9KABESCH M, LAUENER R P. Why old Mcdonald had a farm but no allergies : genes, environments, and the hygiene hypothesis[ J ]. J Leukoc Biol, 2004, 75(3) : 383- 387.
  • 10GERHOLD K, BLUMCHEN K, BOCK A, et al. Endotoxins prevent murine IgE production, T(H)2 immune responses, and development of airway eosinophilia but nor airway hyperreactivity [ J ]. J Allergy Clin Immunol, 2002, 110: 110-116.

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基础医学与临床
2004年 第4期

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