摘要
目的:介绍环氧化酶-2(COX-2)抑制剂预防和治疗肝癌的研究进展及其作用机制。方法:查阅近年来国内外相关文献。结果:COX-2抑制剂在体内和体外试验中均能显著抑制多种肝癌细胞的增殖,诱导其凋亡,并对肿瘤血管生成有抑制作用。结论:COX-2可能成为肿瘤治疗中的一个新靶点,COX-2抑制剂在肝癌的防治中有较好的应用前景,但其有效性和安全性还需进一步研究。
Objective:To introduce the progress and mechanism in HCC prevention and treatment with COX-2 inhibitors.Methods:The correlated articles in recent years have been reviewed.Results:Inhibitors of cyclooxygenase-2(COX-2) markedly inhibit the proliferation and induce the apoptosis of liver cancer cells in vitro and vivo.And they show a significant inhibition to tumorangiogenesis.Conclusion:COX-2 may be a new target for the therapy of cancer.COX-2 inhibitors have a good prospect in HCC chemoprevention and treatment though their effectiveness and safety need to be intensively studied.
出处
《中国药业》
CAS
2004年第12期25-27,共3页
China Pharmaceuticals
关键词
环氧化酶-2
抑制剂
肝癌
cyclooxygenase-2(COX-2)
inhibitors
hepatocellular carcinoma(HCC)
