摘要
目的 :探讨聚维酮联合吡柔比星膀胱灌注预防浅表膀胱癌复发的抗肿瘤免疫效果。方法 :选择5 2例浅表膀胱癌患者 ,采用术前 2 4～ 4 8h及术后灌注。观察组 34例 ,运用聚维酮作为吡柔比星的溶剂行膀胱灌注化疗。对照组 18例 ,运用生理盐水作为吡柔比星的溶剂行膀胱灌注。镜下观察两组肿瘤切除标本间质中的淋巴细胞分布并计数 ,免疫组化法检测S 10 0和CD2 8的表达。结果 :观察组淋巴细胞的计数、S 10 0和CD2 8表达明显高于对照组 (P <0 .0 5 )。结论 :免疫细胞集结分布和增强表达提示聚维酮可能增强机体的抗肿瘤免疫。
Objective:To explore the anti-tumor immunology of intravesical perfusion of polyvinylpyrrolidone together with pirarubicin (PVP/THP) to prevent the recurrence of the superficial bladder cancer.Methods: Fifty two cases were investigated from July 1999 to March 2003.Irrigation was performed in 24～48 hours before operation,THP(20mg) dissolved in 10 ml normal saline plus 20 ml PVP was instilled in observation group, and retained in bladder for 60 minutes.THP(20 mg) dissolved in 30 ml normal saline was infused in another 18 cases(as control group).Lymphocyte count in the interstitial tissues of tumor was observed under light microscopy, S-100 and CD28 expressions were detected with immunohistochemical assay in tumor tissue.Results:The overexpression of CD28 and S-100 in interstitial tissue and lymphocyte count the observation group were obviously higher than that in the control group(P<0.05).Conclusion:Aggregation of the immunological cells and enhancement of expression after PVP irrigation suggest that PVP may strengthen the antitumor immunoresponse.
出处
《温州医学院学报》
CAS
2004年第6期450-451,共2页
Journal of Wenzhou Medical College
基金
温州市科技局科研基金资助项目 (S2 0 0 0A3 9)
关键词
膀胱癌
吡柔比星
聚维酮
淋巴细胞
bladder cancer
pirarubicin
polyvinylpyrrolidone
lymphocytes
