摘要
为了评估丁丙诺啡混合可乐定、丁丙诺啡混合布比卡因以及单纯布比卡因混合生理盐水的镇痛效果以及 不良反应,选择下腹部手术患者45例,随机双盲法分为3组进行术后单次硬膜外腔镇痛。A组:可乐定0.15mg加 丁丙诺啡0.15mg混合后,稀释成0.01L;B组:丁丙诺啡0.15mg加0.2%布比卡因混合后,稀释成0.01L;C组:生 理盐水加0.2%布比卡因混合后,稀释成0.01L。观察3组患者的镇痛效果、镇痛起效时间、持续时间以及血流动力 学变化。结果A组起效时间最快为(4.13±1.62)min,持续时间最长为(1333.67±209.22)min。A组镇痛完全,其 效果明显优于B、C组,但A组出现个别血压下降现象。初步研究结果提示,可乐定可提高丁丙诺啡的硬膜外镇痛效 能,而且是安全、有效的。
We evaluated the analgesic efficacy, side effects of postoperative epidural analgesic infusions of either buprenorphine plus clonidine, buprenorphine plus bupivacaine or bupivacaine plus 0.9% NaCl after surgery. The forty-five patients undergoing bottom abdominal surgical operation were randomized, double-blind divided into three single epidural infusion groups: A, 0.15 mg buprenorphine added to 0.15 mg clonidine; B,0.15 mg buprenorphine added to 0.2% bupivacaine; C, 0.2% bupivacaine added to 0.9% NaCl. All solutions were diluted with saline to 0.01 L. The efficacy of analgesia, the time for sensory block, the duration of analgesia and hemodynamic effects were monitored during epidural analgesia in each group. The time for sensory block in Group A was the fastest (A:4.13±1.62 min ), the duration of analgesia in group A was the longest (A:1 333.67±209.22 min) and the efficacy of analgesia in group A was the best in the three groups. But a few patients had hemodynamic depression in Group A. A significant improvement in postoperative analgesic efficacy was demonstrated with the epidural administration of the combination of buprenorphine with clonidine in patients after bottom abdominal surgical procedures as compared with other groups. We implicate: The addition of clonidine to buprenorphine significantly increases the analgesia after surgery. The results of this study support the use of epidural analgesic infusions of buprenorphine with clonidine is safe and effective.
出处
《肿瘤防治杂志》
2005年第1期72-74,共3页
China Journal of Cancer Prevention and Treatment
关键词
可乐定
丁丙诺啡
布比卡因
术后期间
镇痛
clonidine
buprenorphine
bupivacaine
postoperative period
analgesia
