摘要
目的:比较在同一地高辛血药浓度水平下,单纯老年心衰患者及心衰伴糖尿病患者的游离地高辛浓度的差异,为临床制订合理的地高辛用药方案提供可靠的实验室数据。方法:18例地高辛适应症患者按是否伴有糖尿病分为两组,A组为单纯心衰患者,B组为心衰伴糖尿病患者。分别用FPIA方法测定患者地高辛血药浓度,用超滤-FPIA法测定血清中游离地高辛浓度。结果:地高辛总浓度和游离浓度,A组分别为(1.286±0.294)ng/mL,(0.626±0.106)ng/mL,B组分别为(1.45±0.417)ng/mL,(0.870±0.190)ng/mL。结论:在地高辛总浓度处于同一水平的情况下,心衰伴糖尿病患者与单纯心衰患者的游离地高辛浓度具有统计学差异,前者浓度和游离百分率均明显高于后者(P<0.05)。
Objective:The old patients of heart failure only and heart failure accompanied with diabetes were selected.To find out the differences of their free digoxin concentrations when total concentrations were at the same level and provide the laboratory data for designing the administration project of digoxin.Methods:18 patients were divided into two groups,patients with heart failure only belong to group A;patients with heart failure and diabetes belong to group B.FPIA method was used for monitoring digoxin concentration.The test was used to analyse the results.Results:Total concentration and free concentration of group A were 1.286±0.294(0.81,1.63)ng/mL and 0.626±0.106(0.42,0.74)ng/mL,respectively.Total concentration and free concentration of group B were 1.45±0.417(0.88,1.98)ng/mL and 0.870±0.190(0.59,1.07)ng/mL,respectively.Conclusion:Free concentration of group A is much lower than it in group B(P < 0.05)when their total concentration are the same.
出处
《中国药业》
CAS
2005年第1期64-65,共2页
China Pharmaceuticals
