摘要
为探讨女性绝经后骨质疏松症(postmenopausal osteoporosis PMO)患者骨密度(bone mineral density BMD)和性激素水平的变化与不同肾虚证型之间的内在联系,为临床辨证论治提供客观诊断依据。选择88例肾虚证PMO患者为研究对象,其中肾气虚组37例,肾阴虚组29例,肾阳虚组22例,另设对照组30例,同步检测骨密度、血清睾酮(T)和雌二醇(E2),计算E2／T并进行统计学分析。结果PMO患者骨密度随肾气虚、肾阴虚、肾阳虚依次下降,其中肾阳虚组较对照组和肾气虚组显著下降(P<0.01);PMO不同肾虚证型组骨密度变化均为Want>Neck>Troch。与对照组比较,不同肾虚证型组T显著升高(P<0.01),性激素T水平的变化按肾气虚、肾阴虚、肾阳虚逐渐升高,而E2、E2／T则逐渐降低;不同肾虚证型组E2、E2／T较对照组显著下降(P<0.01)。表明①PMO患者骨密度随肾气虚、肾阴虚、肾阳虚依次下降,不同肾虚证型组骨密度变化均为Troch>Neck>Ward;②PMO患者性激素T水平的变化按肾气虚、肾阴虚、肾阳虚逐渐升高,而E2、E2／T则逐渐降低;③骨密度和性激素水平反应了肾虚程度,即依肾气虚-肾阴虚-肾阳虚逐渐加重。④骨密度测定值和性激素水平的变化可作为PMO不同肾虚证型的客观评价指标,并为PMO患者不同肾虚证型的治疗效果的观察提供参考依据。
The objective of the paper is to study the inherent relation between the level change of BMD and sexual hormone in postmenopausal osteoporosis (PMO) and the different kidney deficiency syndromes (KDS) as to offer the objective diagnostic basis for the clinical treatment according to the differentiated syndromes. Eighty-eight PMO cases of KDS were selected as the studied subjects, including 37 cases of kidney Qi deficiency (KQD), 29 of kidney Yin deficiency (KYD), 22 of kidney Yang deficiency (KYGD) and 30 of the control (C); the BMD, serum testosterone (T) and estradiol (E2) were measured by DEXA and automatic biochemical analyzer; E2/T were calculated and statistically analyzed. The results showed that BMD in PMO patients descent in order; KQD, KYD and KYGD with the BMD descent in KYGD much greater than those in C and KQD (P < 0.01) and with BMD changes of the varied KDS groups: Ward > neck > troch; compared with C, the T levels of varied KDS ascended significantly in order: KQD, KYD and KYGD (P < 0.01), while E2 and E2/T descent gradually; E2 and E2/T of the different KDS descent obviously compared with C (P < 0.01), suggesting: ① BMD in MO patients descent in order: KQD, KYD and KYGD; BMD in varied KDS changed: troch > neck > Ward. ② The T level in PMO patients ascended gradually in order: KQD, KYD and KYGD, while E2 and E2/ T descent gradually. ③ Kidney deficiency severity may be reflected by BMD and sexual hormone level, that is, exacerbated gradually in order: KQD, KYD and KYGD. ④ The detected BMD value and sexual hormone level change may be used as the objective evaluating indices of varied KDS, offering the reference basis for observing the therapeutic effect on various KDS of PMO patients.
出处
《中医正骨》
2005年第2期3-5,共3页
The Journal of Traditional Chinese Orthopedics and Traumatology
关键词
绝经后骨质疏松症/诊断
骨密度
性激素
肾虚证
实验研究
postmenopausal osteoporosis/diagnosis, BMD, sexual hormone, kidney deficiency syndromes, experimental study
